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一种通过分布式差分放大器实现的具有密度可扩展有源读出像素的4.8微伏噪声CMOS微电极阵列。

A 4.8-μV-Noise CMOS-Microelectrode Array With Density-Scalable Active Readout Pixels via Disaggregated Differential Amplifier Implementation.

作者信息

Ogi Jun, Kato Yuri, Nakashima Yusaku, Ikeda Kenji, Jingu Motoko, Matoba Yoshihisa, Kimizuka Naohiko, Yamane Chigusa, Maehara Masataka, Kishimoto Takuya, Hashimoto Shigeki, Matsui Eriko, Oike Yusuke

机构信息

Research Division 1, Sony Semiconductor Solutions Corporation, Kanagawa, Japan.

Department of Biomedical Research, R&D Center, Sony Corporation, Tokyo, Japan.

出版信息

Front Neurosci. 2019 Mar 21;13:234. doi: 10.3389/fnins.2019.00234. eCollection 2019.

DOI:10.3389/fnins.2019.00234
PMID:30949022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6437115/
Abstract

We demonstrate a 4.8-μV noise microelectrode array (MEA) based on the complementary-metal-oxide-semiconductor active-pixel-sensors readout technique with disaggregated differential amplifier implementation. The circuit elements of the differential amplifier are divided into a readout pixel, a reference pixel, and a column circuit. This disaggregation contributes to the small area of the readout pixel, which is less than 81 μm. We observed neuron signals around 100 μV with 432 electrodes in a fabricated prototype chip. The implementation has technological feasibility of up to 12-μm-pitch electrode density and 6,912 readout channels for high-spatial resolution mapping of neuron network activity.

摘要

我们展示了一种基于互补金属氧化物半导体有源像素传感器读出技术并采用分布式差分放大器实现的4.8微伏噪声微电极阵列（MEA）。差分放大器的电路元件被分为一个读出像素、一个参考像素和一个列电路。这种分布式设计有助于减小读出像素的面积，该面积小于81平方微米。在一个制造的原型芯片中，我们用432个电极观测到了约100微伏的神经元信号。该实现方式具有高达12微米间距电极密度和6912个读出通道的技术可行性，可用于神经元网络活动的高空间分辨率映射。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/62b6bca44112/fnins-13-00234-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/ba2a06d19d71/fnins-13-00234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/5f99c7a3cb52/fnins-13-00234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/a047c91e5743/fnins-13-00234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/b4e7eeaebb71/fnins-13-00234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/157efdd4be2b/fnins-13-00234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/836fa058eec4/fnins-13-00234-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/e58b3798099e/fnins-13-00234-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/62b6bca44112/fnins-13-00234-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/ba2a06d19d71/fnins-13-00234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/5f99c7a3cb52/fnins-13-00234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/a047c91e5743/fnins-13-00234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/b4e7eeaebb71/fnins-13-00234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/157efdd4be2b/fnins-13-00234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/836fa058eec4/fnins-13-00234-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/e58b3798099e/fnins-13-00234-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf0/6437115/62b6bca44112/fnins-13-00234-g008.jpg

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本文引用的文献

1
Twenty-four-micrometer-pitch microelectrode array with 6912-channel readout at 12 kHz via highly scalable implementation for high-spatial-resolution mapping of action potentials.通过高度可扩展的实现方式，以12千赫兹的频率对具有6912个通道读出的24微米间距微电极阵列进行动作电位的高空间分辨率映射。
Biointerphases. 2017 Dec 19;12(5):05F402. doi: 10.1116/1.4997358.
2
A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro.一种具有26400个电极的1024通道CMOS微电极阵列，用于体外记录和刺激电生细胞。
IEEE J Solid-State Circuits. 2014 Nov;49(11):2705-2719. doi: 10.1109/JSSC.2014.2359219.
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Revealing neuronal function through microelectrode array recordings.
通过微电极阵列记录揭示神经元功能。
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Single-cell recording and stimulation with a 16k micro-nail electrode array integrated on a 0.18 μm CMOS chip.在 0.18μm CMOS 芯片上集成的 16k 微钉电极阵列进行单细胞记录和刺激。
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