Imfeld Kilian, Neukom Simon, Maccione Alessandro, Bornat Yannick, Martinoia Sergio, Farine Pierre-André, Koudelka-Hep Milena, Berdondini Luca
Electronics and Signal Processing Laboratory, Institute of Microtechnology, University of Neuchâtel, CH-2000 Neuchâtel, Switzerland.
IEEE Trans Biomed Eng. 2008 Aug;55(8):2064-73. doi: 10.1109/TBME.2008.919139.
A platform for high spatial and temporal resolution electrophysiological recordings of in vitro electrogenic cell cultures handling 4096 electrodes at a full frame rate of 8 kHz is presented and validated by means of cardiomyocyte cultures. Based on an active pixel sensor device implementing an array of metallic electrodes, the system provides acquisitions at spatial resolutions of 42 microm on an active area of 2.67 mm x 2.67 mm, and in the zooming mode, temporal resolutions down to 8 micros on 64 randomly selected electrodes. The low-noise performances of the integrated amplifier (11 microV (rms)) combined with a hardware implementation inspired by image/video processing concepts enable high-resolution acquisitions with real-time preprocessing capabilities adapted to the handling of the large amount of acquired data.
本文介绍了一种用于体外电生细胞培养物高空间和时间分辨率电生理记录的平台，该平台可在8 kHz的全帧率下处理4096个电极，并通过心肌细胞培养进行了验证。该系统基于一个实现金属电极阵列的有源像素传感器设备，在2.67 mm x 2.67 mm的有源区域上提供42微米的空间分辨率采集，在缩放模式下，在64个随机选择的电极上时间分辨率低至8微秒。集成放大器的低噪声性能（11微伏（均方根））与受图像/视频处理概念启发的硬件实现相结合，实现了具有实时预处理能力的高分辨率采集，适用于处理大量采集数据。
