Association of antieosinophil therapy with decreased body mass index in patients with severe asthma: A preliminary retrospective analysis.
作者信息
Kuruvilla Merin, Patrawala Meera, Levy Joshua M, Shih Jennifer, Lee Frances E
机构信息
Division of Pulmonary, Allergy, and Critical Care, Emory University School of Medicine, Atlanta, Georgia.
Division of Pulmonary, Allergy, and Critical Care, Emory University School of Medicine, Atlanta, Georgia.
出版信息
Ann Allergy Asthma Immunol. 2019 Jun;122(6):649-650. doi: 10.1016/j.anai.2019.03.031. Epub 2019 Apr 4.
Abstract
摘要
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Obesity-induced reduction of adipose eosinophils is reversed with low-calorie dietary intervention.肥胖引起的脂肪组织嗜酸性粒细胞减少可通过低热量饮食干预得到逆转。
Physiol Rep. 2018 Nov;6(22):e13919. doi: 10.14814/phy2.13919.
2
Defining Eosinophil Function in Adiposity and Weight Loss.定义嗜酸性粒细胞在肥胖和体重减轻中的功能。
Bioessays. 2018 Oct;40(10):e1800098. doi: 10.1002/bies.201800098. Epub 2018 Aug 22.
3
Eosinophils support adipocyte maturation and promote glucose tolerance in obesity.嗜酸性粒细胞支持脂肪细胞成熟，并促进肥胖中的葡萄糖耐量。
Sci Rep. 2018 Jul 2;8(1):9894. doi: 10.1038/s41598-018-28371-4.
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Toward an Understanding of How Immune Cells Control Brown and Beige Adipobiology.浅析免疫细胞调控棕色和米色脂肪生物学的机制。
Cell Metab. 2018 May 1;27(5):954-961. doi: 10.1016/j.cmet.2018.04.006.
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Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments.将肥胖小鼠的脂肪嗜酸性粒细胞提升至生理正常水平并不能挽救代谢损伤。
Mol Metab. 2018 Feb;8:86-95. doi: 10.1016/j.molmet.2017.12.004. Epub 2017 Dec 16.
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Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma.肥胖的重症哮喘患者痰中白细胞介素-5 水平升高和黏膜下嗜酸性粒细胞增多。
Am J Respir Crit Care Med. 2013 Sep 15;188(6):657-63. doi: 10.1164/rccm.201208-1470OC.
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Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.嗜酸性粒细胞维持与葡萄糖稳态相关的脂肪组织中选择性激活的巨噬细胞。
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