Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Department of Cardiovascular Surgery, General Hospital of Guangzhou Military Command of PLA, 111 Liuhua Road, Guang Zhou 510010, China.
Department of Aerospace Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
Ageing Res Rev. 2019 Jul;52:17-31. doi: 10.1016/j.arr.2019.04.001. Epub 2019 Apr 4.
Fibrosis is universally observed in multiple aging-related diseases and progressions and is characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various human organs and eventually results in organ failure. Noncoding RNAs (ncRNAs) have emerged as essential regulators of cellular signaling and relevant human diseases. In particular, the enigmatic class of long noncoding RNAs (lncRNAs) is a kind of noncoding RNA that is longer than 200 nucleotides and does not possess protein coding ability. LncRNAs have been identified to exert both promotive and inhibitory effects on the multifaceted processes of fibrosis. A growing body of studies has revealed that lncRNAs are involved in fibrosis in various organs, including the liver, heart, lung, and kidney. As lncRNAs have been increasingly identified, they have become promising targets for anti-fibrosis therapies. This review systematically highlights the recent advances regarding the roles of lncRNAs in fibrosis and sheds light on the use of lncRNAs as a potential treatment for fibrosis.
纤维化普遍存在于多种与衰老相关的疾病和进展中，其特征是细胞外基质的过度积累。纤维化发生在各种人类器官中，最终导致器官衰竭。非编码 RNA（ncRNAs）已成为细胞信号转导和相关人类疾病的重要调节剂。特别是，神秘的长非编码 RNA（lncRNAs）类是非编码 RNA，长度超过 200 个核苷酸，不具有蛋白质编码能力。已经确定 lncRNAs 对纤维化的多方面过程具有促进和抑制作用。越来越多的研究表明，lncRNAs 参与了包括肝脏、心脏、肺和肾脏在内的各种器官的纤维化。随着 lncRNAs 的不断被发现，它们已成为抗纤维化治疗的有希望的靶点。本综述系统地强调了 lncRNAs 在纤维化中的作用的最新进展，并探讨了将 lncRNAs 用作纤维化潜在治疗方法的可能性。
