Akbari Kordkheyli Vahid, Khonakdar Tarsi Abbas, Mishan Mohammad A, Tafazoli Alireza, Bardania Hassan, Zarpou Setareh, Bagheri Abouzar
Department of Clinical Biochemistry-Biophysics and Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Cell Biochem. 2019 Aug;120(8):12141-12155. doi: 10.1002/jcb.28663. Epub 2019 Apr 7.
MicroRNA (miRNA)-dependent pathways are one of the newest gene regulation mechanisms in various diseases, particularly in cancers. miRNAs are endogenous noncoding RNAs with about 18 to 25 nucleotide length, which can regulate the expression of at least 60% of human total genome posttranscriptionally. Quercetin is the most abundant flavonoid in a variety of fruits, flowers, and medical herbs, known as a strong free radical scavenger that could show antioxidant, anti-inflammatory, and antitumor activities. Recent studies also reported its strong impact on various miRNA expressions in different abnormalities. In this review, we aimed to summarize the studies focused on the effects of quercetin on different miRNA expressions to more clear the main possible mechanisms of quercetin influences and introduce it as a beneficial agent for regulation of miRNAs in various biological directions.
微小RNA（miRNA）依赖的途径是各种疾病，尤其是癌症中最新的基因调控机制之一。miRNA是长度约为18至25个核苷酸的内源性非编码RNA，可在转录后调节至少60%的人类基因组的表达。槲皮素是各种水果、花卉和药草中含量最丰富的黄酮类化合物，是一种强大的自由基清除剂，具有抗氧化、抗炎和抗肿瘤活性。最近的研究还报道了它对不同异常情况下各种miRNA表达的强烈影响。在这篇综述中，我们旨在总结关于槲皮素对不同miRNA表达影响的研究，以更清楚地了解槲皮素影响的主要可能机制，并将其作为一种在各种生物学方向上调节miRNA的有益试剂进行介绍。
