Huang Aimin, Li Xuanhai, Liang Xingtang, Zhang Yanjuan, Hu Huayu, Yin Yanzhen, Huang Zuqiang
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
Medical College of Guangxi University, Nanning 530004, China.
Polymers (Basel). 2018 Dec 13;10(12):1381. doi: 10.3390/polym10121381.
Emamectin benzoate (EB), a widely used pesticide, is prone to decomposition by ultraviolet light and suffers from the corresponding loss of efficacy. The timed release of EB based on microspheres is one of the effective methods to solve this issue. As a non-toxic cellulose ester, cellulose acetate butyrate (CAB) is regarded as one of the best wall-forming materials for microcapsules with a good controlled release performance. Herein, two methods-mechanical activation (MA) technology and a conventional liquid phase (LP) method-were employed to synthesize different CABs, namely CAB-MA and CAB-LP, respectively. The molecular structure, rheological property, and thermal stability of these CABs were investigated. The two CABs were used to prepare microspheres for the loading and release of EB via an o/w (oil-in-water) solvent evaporation method. Moreover, the performances such as drug loading, drug entrapment, and anti-photolysis of the drug for these microspheres were studied. The results showed that both CABs were available as wall materials for loading and releasing EB. Compared with CAB-LP, CAB-MA presented a lower molecular weight and a narrower molecular weight distribution. Moreover, the MA method endowed the CAB with more ester substituent groups and less crystalline structure in comparison to the LP method, which had benefits including pelletizing and drug loading.
苯甲酸阿维菌素（EB）是一种广泛使用的杀虫剂，容易被紫外线分解并导致相应的药效损失。基于微球的EB定时释放是解决这一问题的有效方法之一。作为一种无毒的纤维素酯，醋酸丁酸纤维素（CAB）被认为是具有良好控释性能的微胶囊最佳壁材之一。在此，分别采用机械活化（MA）技术和传统液相（LP）法这两种方法合成了不同的CAB，即CAB-MA和CAB-LP。研究了这些CAB的分子结构、流变性能和热稳定性。通过水包油（o/w）溶剂蒸发法，将这两种CAB用于制备负载和释放EB的微球。此外，还研究了这些微球的载药量、药物包封率和药物抗光解等性能。结果表明，两种CAB都可作为负载和释放EB的壁材。与CAB-LP相比，CAB-MA的分子量较低且分子量分布较窄。此外，与LP法相比，MA法赋予CAB更多的酯取代基和更少的晶体结构，这有利于制粒和载药。
