Bay Dermatology Centre, Toronto, Ontario, Canada.
Radboud UMC Nijmegen, Andriessen Consultants, Malden, The Netherlands.
J Cosmet Dermatol. 2019 Jun;18(3):815-820. doi: 10.1111/jocd.12927. Epub 2019 Apr 9.
The skin exposome refers to the constellation of external exposures that contribute to cutaneous aging, including solar radiation, air pollution, tobacco smoke, unbalanced nutrition, and cosmetic products. This review explores the skin exposome and the role of a combination hyaluronic acid and mineralized thermal water product used to restore and maintain optimal skin barrier function.
An expert panel of 7 dermatologists who treat clinical signs of facial aging convened for a one-day meeting to discuss the results of a literature review on the skin exposome and the role of M89, a mineralized thermal water and hyaluronic acid-based gel, to improve the quality of facial skin. Evidence coupled with expert opinion and experience of the panel was used to address clinical challenges in the treatment of photo-aging, and the use of M89.
Solar radiation (ultraviolet radiation, visible light, and infrared radiation), air pollution, tobacco smoke, nutrition, and miscellaneous factors, including stress, sleep deprivation, and temperature, may potentiate skin aging by triggering molecular processes that damage skin structure. M89 was developed to maintain and restore skin and contains ingredients to aid physical, hydric, antioxidant, and antimicrobial skin barrier function.
Increasing knowledge of the exposome and microenvironment contributing to skin aging may support a better understanding of measures to support the skin. The initial results of in vitro and clinical studies of M89 show its potential to improve skin barrier function.
皮肤外显组是指导致皮肤衰老的外部暴露因素的组合,包括太阳辐射、空气污染、烟草烟雾、营养失衡和化妆品。本综述探讨了皮肤外显组以及一种用于恢复和维持最佳皮肤屏障功能的组合透明质酸和矿化温泉水产品的作用。
一个由 7 位治疗面部衰老临床征象的皮肤科专家组成的专家小组召开了为期一天的会议,讨论了关于皮肤外显组和 M89(一种基于矿化温泉水和透明质酸的凝胶)作用的文献综述的结果,以改善面部皮肤质量。证据结合专家意见和小组的经验,解决了光老化治疗中的临床挑战,以及 M89 的使用问题。
太阳辐射(紫外线辐射、可见光和红外线辐射)、空气污染、烟草烟雾、营养以及包括压力、睡眠剥夺和温度在内的其他因素,可能通过触发损害皮肤结构的分子过程来加速皮肤衰老。M89 的开发是为了维持和恢复皮肤,并含有有助于物理、水合、抗氧化和抗菌皮肤屏障功能的成分。
对外显组和导致皮肤衰老的微环境的认识不断提高,可能有助于更好地理解支持皮肤的措施。M89 的体外和临床研究的初步结果表明,它具有改善皮肤屏障功能的潜力。