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透气止血水凝胶敷料的制备、表征及其对全层缺损影响的测定

Preparation and Characterization of Breathable Hemostatic Hydrogel Dressings and Determination of Their Effects on Full-Thickness Defects.

作者信息

Pan Hong, Fan Daidi, Cao Wei, Zhu Chenhui, Duan Zhiguang, Fu Rongzhan, Li Xian, Ma Xiaoxuan

机构信息

College of Chemistry & Materials Science, Northwest University, Taibai North Road 229, Xi'an 710069, Shaanxi, China.

Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an 710069, Shaanxi, China.

出版信息

Polymers (Basel). 2017 Dec 18;9(12):727. doi: 10.3390/polym9120727.

DOI:10.3390/polym9120727
PMID:30966027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6418977/
Abstract

Hydrogel-based wound dressings provide a cooling sensation, a moist environment, and act as a barrier to microbes for wounds. In this study, a series of soft, flexible, porous non-stick hydrogel dressings were prepared through the simple repeated freeze-thawing of a poly(vinyl alcohol), human-like collagen (or and carboxymethyl chitosan) mixed solution rather than chemical cross-linking and Tween80 was added as pore-forming agent for cutaneous wound healing. Some of their physical and chemical properties were characterized. Interestingly, hydrogel PVA-HLC-T80 and PVA-HLC-CS-T80 presented excellent swelling ratios, bacterial barrier activity, moisture vapor permeability, hemostasis activity and biocompatibility. Furthermore, in vivo evaluation of the healing capacity of these two hydrogels was checked by creating a full-thickness wound defect (1.3 cm × 1.3 cm) in rabbit. Macroscopic observation and subsequent hematoxylin eosin staining (H&E) staining and transmission electron microscopy (TEM) analysis at regular time intervals for 18 days revealed that the hydrogels significantly enhanced wound healing by reducing inflammation, promoting granulation tissue formation, collagen deposition and accelerating re-epithelialization. Taken together, the obtained data strongly encourage the use of these multifunctional hydrogels for skin wound dressings.

摘要

水凝胶基伤口敷料可为伤口提供清凉感、潮湿环境，并作为微生物屏障。在本研究中，通过对聚乙烯醇、类人胶原蛋白（或羧甲基壳聚糖）混合溶液进行简单的反复冻融而非化学交联来制备一系列柔软、灵活、多孔的不粘水凝胶敷料，并添加吐温80作为用于皮肤伤口愈合的造孔剂。对其一些物理和化学性质进行了表征。有趣的是，水凝胶PVA-HLC-T80和PVA-HLC-CS-T80具有优异的溶胀率、细菌屏障活性、透湿性、止血活性和生物相容性。此外，通过在兔子身上制造全层伤口缺损（1.3 cm×1.3 cm）来检查这两种水凝胶愈合能力的体内评估。在18天内定期进行宏观观察以及随后的苏木精伊红染色（H&E）和透射电子显微镜（TEM）分析表明，水凝胶通过减轻炎症、促进肉芽组织形成、胶原蛋白沉积和加速再上皮化，显著促进了伤口愈合。综上所述，所获得的数据有力地支持了将这些多功能水凝胶用于皮肤伤口敷料。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40af/6418977/6da7a46ce9dc/polymers-09-00727-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40af/6418977/26a4f6f25e37/polymers-09-00727-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40af/6418977/935009349367/polymers-09-00727-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40af/6418977/529b261eb20d/polymers-09-00727-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40af/6418977/9708ab3f5bf6/polymers-09-00727-g018.jpg
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