School of Biotechnology, National Institute of Technology Calicut, Kozhikode, India.
Department of Pharmacology, Khalsa College of Pharmacy, Amritsar, Punjab, India.
Sci Rep. 2022 Aug 12;12(1):13735. doi: 10.1038/s41598-022-17054-w.
Proper burn wound management considers patient's compliance and provides an environment to accelerate wound closure. Sticky hydrogels are conducive to wound management. They can act as a preventive infection patch with controlled drug delivery and diverse surface adherence. A hypothesis-driven investigation explores a bioinspired polydopamine property in a gelatin-based hydrogel (GbH) where polyvinyl alcohol and starch function as hydrogel backbone. The GbH displayed promising physical properties with O-H group rich surface. The GbH was sticky onto dry surfaces (glass, plastic and aluminium) and wet surfaces (pork and chicken). The GbH demonstrated mathematical kinetics for a transdermal formulation, and the in vitro and in vivo toxicity of the GbH on test models confirmed the models' healthy growth and biocompatibility. The quercetin-loaded GbH showed 45-50% wound contraction on day 4 for second-degree burn wounds in rat models that were equivalent to the silver sulfadiazine treatment group. The estimates for tensile strength, biochemicals, connective tissue markers and NF-κB were restored on day 21 in the GbH treated healed wounds to imitate the normal level of the skin. The bioinspired GbH promotes efficient wound healing of second-degree burn wounds in rat models, indicating its pre-clinical applicability.
恰当的烧伤创面管理需要考虑患者的依从性，并为创面愈合提供有利环境。粘性水凝胶有利于创面管理。它们可以作为一种具有控释药物和多种表面附着功能的预防性抗感染贴片。本假说驱动研究探索了一种基于明胶的水凝胶（GbH）中的生物启发型聚多巴胺特性，其中聚乙烯醇和淀粉作为水凝胶骨架。GbH 具有丰富的 O-H 基团表面，显示出有前景的物理性能。GbH 可粘贴在干燥表面（玻璃、塑料和铝）和湿润表面（猪肉和鸡肉）。GbH 对透皮制剂表现出数学动力学，GbH 对试验模型的体外和体内毒性证实了模型的健康生长和生物相容性。载有槲皮素的 GbH 在大鼠模型的二度烧伤创面第 4 天收缩 45-50%，与磺胺嘧啶银治疗组相当。在 GbH 治疗愈合创面的第 21 天，拉伸强度、生物化学物质、结缔组织标志物和 NF-κB 的估计值恢复到正常皮肤水平。这种生物启发型 GbH 促进了大鼠模型二度烧伤创面的有效愈合，表明其具有临床前适用性。
