从 R.A. 费希尔 1918 年的论文到一个世纪后的 GWAS。
From R.A. Fisher's 1918 Paper to GWAS a Century Later.
机构信息
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia 4072.
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia 4072.
出版信息
Genetics. 2019 Apr;211(4):1125-1130. doi: 10.1534/genetics.118.301594.
Abstract
The genetics and evolution of complex traits, including quantitative traits and disease, have been hotly debated ever since Darwin. A century ago, a paper from R.A. Fisher reconciled Mendelian and biometrical genetics in a landmark contribution that is now accepted as the main foundation stone of the field of quantitative genetics. Here, we give our perspective on Fisher's 1918 paper in the context of how and why it is relevant in today's genome era. We mostly focus on human trait variation, in part because Fisher did so too, but the conclusions are general and extend to other natural populations, and to populations undergoing artificial selection.
摘要
复杂性状（包括数量性状和疾病）的遗传学和进化自达尔文以来一直备受争议。一个世纪前，R.A. 费希尔的一篇论文调和了孟德尔遗传学和生物统计学遗传学，这一里程碑式的贡献现在被认为是数量遗传学领域的主要基石。在这里，我们根据它在当今基因组时代的相关性和原因，从我们的角度来讨论费希尔 1918 年的论文。我们主要关注人类特征变异，部分原因是费希尔也是如此，但结论是普遍的，适用于其他自然种群和正在经历人工选择的种群。
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