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作为人类卵巢癌潜在的预后生物标志物和靶点。

Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer.

作者信息

Zhou Quan, Zhang Fan, He Ze, Zuo Man-Zhen

机构信息

Department of Gynecology and Obstetrics, The People's Hospital of China Three Gorges University/The First People's Hospital of Yichang, Yichang, China.

出版信息

Front Oncol. 2019 Mar 22;9:161. doi: 10.3389/fonc.2019.00161. eCollection 2019.

DOI:10.3389/fonc.2019.00161
PMID:30967995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6439355/
Abstract

are a family of pivotal transcription factors. Accumulative evidence indicates that aberrant expression or activation of is a common phenomenon in malignances, and significant associations have been noted between and tumorigenesis or progression in a wide range of cancers. However, the expression patterns and exact roles of each contributing to tumorigenesis and progression of ovarian cancer (OC) have not yet been elucidated. In this study, we investigated the distinct expression and prognostic value of E2Fs in patients with OC by analyzing a series of databases, including ONCOMINE, GEPIA, cBioPortal, Metascape, and Kaplan-Meier plotter. The mRNA expression levels of were found to be significantly upregulated in patients with OC and were obviously associated with tumor stage for OC. Aberrant expression of was found to be associated with the clinical outcomes of patients with OC. These results suggest that might serve as potential prognostic biomarkers and targets for OC. However, future studies are required to validate our findings and promote the clinical utility of in OC.

摘要

E2F 是一类关键的转录因子。越来越多的证据表明，E2F 的异常表达或激活在恶性肿瘤中是一种常见现象，并且在多种癌症的肿瘤发生或进展与 E2F 之间已发现显著关联。然而，E2F 在卵巢癌（OC）的肿瘤发生和进展中的各自表达模式及确切作用尚未阐明。在本研究中，我们通过分析一系列数据库，包括 ONCOMINE、GEPIA、cBioPortal、Metascape 和 Kaplan-Meier plotter，研究了 OC 患者中 E2F 的不同表达及预后价值。发现 OC 患者中 E2F 的 mRNA 表达水平显著上调，并且与 OC 的肿瘤分期明显相关。还发现 E2F 的异常表达与 OC 患者的临床结局相关。这些结果表明，E2F 可能作为 OC 的潜在预后生物标志物和靶点。然而，需要进一步研究来验证我们的发现并促进 E2F 在 OC 中的临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/b9489ff44f37/fonc-09-00161-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/19c305f98f87/fonc-09-00161-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/86605e351e11/fonc-09-00161-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/5ebc7cd3b4dd/fonc-09-00161-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/b9df1ee9039b/fonc-09-00161-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/2be7f6ddd4df/fonc-09-00161-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/c94a335c3729/fonc-09-00161-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/b9489ff44f37/fonc-09-00161-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/19c305f98f87/fonc-09-00161-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/86605e351e11/fonc-09-00161-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/5ebc7cd3b4dd/fonc-09-00161-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/b9df1ee9039b/fonc-09-00161-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/2be7f6ddd4df/fonc-09-00161-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/c94a335c3729/fonc-09-00161-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7cf/6439355/b9489ff44f37/fonc-09-00161-g0007.jpg

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