Department of Pathophysiology, Medical University of Gdansk, Faculty of Medicine, Gdańsk, Poland.
Department of Psychiatry, Medical University of Gdansk, Faculty of Medicine, Gdańsk, Poland.
Sci Rep. 2019 Apr 10;9(1):5869. doi: 10.1038/s41598-019-42482-6.
We investigated the phenotype of peripheral blood lymphocytes of patients with bipolar disorder type II in different phases of the disease in order to check whether there are specific changes in the immune parameters. Lymphocytes subpopulations were analyzed ex vivo with flow cytometry in patients in euthymic, depression or hypomanic phase of the disease and compared with healthy controls. All BD patients were characterized by lower percentage of CD3CD4 and CD3CD8 cells compared with healthy people. But only patients in depression and remission had higher percentage of B cells (CD19 cells) compared with healthy people. The percentage of CD4CD25 and CD8CD25 cells was decreased in patients in hypomanic phase compared with healthy control. Patients in remission were characterized by increased concentrations of IL-6 and IL-10 and decreased level of TNF in blood serum. Significant correlations between immunologic parameters and the results of Hamilton or Young scale have also been found. Our results demonstrate that there are significant differences in lymphocyte subpopulations which depend on the phase of the disease the patient is currently in.
我们研究了双相情感障碍 II 型患者在疾病不同阶段外周血淋巴细胞的表型，以检查免疫参数是否存在特异性变化。使用流式细胞术分析了处于缓解期、抑郁期或轻躁狂期的患者的淋巴细胞亚群，并与健康对照组进行了比较。所有 BD 患者的 CD3CD4 和 CD3CD8 细胞百分比均低于健康人。但只有抑郁和缓解期的患者的 B 细胞（CD19 细胞）百分比高于健康人。与健康对照组相比，轻躁狂期患者的 CD4CD25 和 CD8CD25 细胞百分比降低。缓解期患者的血清中 IL-6 和 IL-10 浓度增加，TNF 水平降低。还发现免疫参数与 Hamilton 或 Young 量表的结果之间存在显著相关性。我们的结果表明，淋巴细胞亚群存在显著差异，这取决于患者目前所处的疾病阶段。
