从三叶胶种子提取物中分离得到的 4 种柠檬苦素。

Four limonoids from the seeds extract of Sandoricum koetjape.

机构信息

Organic Chemistry Division, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, Indonesia.

Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Pakuan, Bogor, Indonesia.

出版信息

J Nat Med. 2019 Jun;73(3):641-647. doi: 10.1007/s11418-019-01303-w. Epub 2019 Apr 10.

DOI:10.1007/s11418-019-01303-w

PMID:30972689

Abstract

Three andirobin- and one trijugin-class limonoids, named koetjapins A-D (1-4), have been isolated from the seed extracts of Sandoricum koetjape. The structures of these compounds were determined by extensive NMR and mass spectral data, and the chemotaxonomic significance of these limonoids in the family Meliaceae is highlighted. Preliminary biological activity showed that only compound 4 has significant inhibitory activity against P-388 cells, while antibacterial tests showed that none of these compounds were active.

摘要

从三尖杉和麻疯树种子提取物中分离得到三种和一叶萩烷型和一种三尖杉烷型柠檬苦素，分别命名为 koetjapin A-D（1-4）。通过广泛的 NMR 和质谱数据分析确定了这些化合物的结构，并强调了这些柠檬苦素在楝科中的化学分类学意义。初步的生物活性测试表明，只有化合物 4 对 P-388 细胞具有显著的抑制活性，而抗菌测试表明这些化合物均无活性。