Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cell Host Microbe. 2019 Apr 10;25(4):484-498. doi: 10.1016/j.chom.2019.03.009.
Host genetic variation has a major impact on infectious disease susceptibility. The study of pathogen resistance genes, largely aided by mouse models, has significantly advanced our understanding of infectious disease pathogenesis. The Collaborative Cross (CC), a newly developed multi-parental mouse genetic reference population, serves as a tractable model system to study how pathogens interact with genetically diverse populations. In this review, we summarize progress utilizing the CC as a platform to develop improved models of pathogen-induced disease and to map polymorphic host response loci associated with variation in susceptibility to pathogens.
宿主遗传变异对传染病易感性有重大影响。对病原体抗性基因的研究，在很大程度上得益于小鼠模型，极大地促进了我们对传染病发病机制的理解。新近开发的多亲代小鼠遗传参考群体——协作交叉（CC），作为一个易于处理的模型系统，用于研究病原体如何与遗传多样化的群体相互作用。在这篇综述中，我们总结了利用 CC 作为平台来开发改进的病原体诱导疾病模型，以及绘制与病原体易感性变异相关的多态宿主反应基因座图谱的进展。
