National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB, Canada.
Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada.
Sci Rep. 2019 Apr 11;9(1):5954. doi: 10.1038/s41598-019-42355-y.
The complete genome of a novel coronavirus was sequenced directly from the cloacal swab of a Canada goose that perished in a die-off of Canada and Snow geese in Cambridge Bay, Nunavut, Canada. Comparative genomics and phylogenetic analysis indicate it is a new species of Gammacoronavirus, as it falls below the threshold of 90% amino acid similarity in the protein domains used to demarcate Coronaviridae. Additional features that distinguish the genome of Canada goose coronavirus include 6 novel ORFs, a partial duplication of the 4 gene and a presumptive change in the proteolytic processing of polyproteins 1a and 1ab.
直接从在加拿大努纳武特剑桥湾死亡的加拿大鹅和雪雁的泄殖腔拭子中对一种新型冠状病毒的完整基因组进行了测序。比较基因组学和系统发育分析表明，它是一种新型的γ冠状病毒，因为它在用于划分冠状病毒科的蛋白结构域中低于 90%的氨基酸相似性阈值。加拿大鹅冠状病毒基因组的其他特征包括 6 个新的 ORF、4 个基因的部分重复以及多蛋白 1a 和 1ab 的蛋白水解加工的推定变化。
