Meel Rachna, Dhiman Rebika, Sen Seema, Kashyap Seema, Tandon Radhika, Vanathi Murugesan
Oculoplasty and Ocular Oncology Services, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Ocular Pathology Services, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Ocul Oncol Pathol. 2019 Feb;5(2):122-127. doi: 10.1159/000490251. Epub 2018 Jul 13.
To study the clinical profile, ultrasound biomicroscopy (UBM) findings, and treatment outcome of ocular surface squamous neoplasia with intraocular extension (OSSN-IO).
It was a retrospective case series of 7 eyes of OSSN-IO treated at our center from March 2015 till December 2016.
Mean age of presentation was 53 years. Clinical signs of intraocular involvement were evident in 3 cases (43%). In the remaining 4 cases (57%), it was diagnosed on UBM alone. Mean tumor height on UBM was 5.06 mm (6.6 mm for nodular and 3.8 mm for nodulo-ulcerative pattern). Of 7 cases, 2 were managed with exenteration, 4 cases with enucleation + limited excision ± external beam radiotherapy, and 1 was lost to follow-up. Complete regression was noted in 83% cases (5/6) and they remain disease free at a mean follow-up of 23.2 months. One case died of metastasis at 7 months. Histopathological examination showed well- to moderately differentiated tumor in all cases.
Use of UBM in high-risk OSSN cases may help pick up IO invasion. Tumors that are at high risk for IO invasion are thick nodular tumors (> 5 mm), tumors with nodular or ulcerative morphology, and those with prior surgical intervention.
研究伴有眼内侵犯的眼表鳞状上皮肿瘤（OSSN-IO）的临床特征、超声生物显微镜（UBM）检查结果及治疗效果。
这是一项回顾性病例系列研究，纳入了2015年3月至2016年12月在本中心接受治疗的7例OSSN-IO患者的7只眼。
患者的平均就诊年龄为53岁。3例（43%）有明显的眼内受累临床体征。其余4例（57%）仅通过UBM检查确诊。UBM检查显示肿瘤平均高度为5.06 mm（结节型为6.6 mm，结节溃疡型为3.8 mm）。7例患者中，2例行眼球摘除术，4例行眼球摘除术+有限切除术±外照射放疗，1例失访。83%的病例（5/6）完全缓解，平均随访23.2个月时仍无疾病复发。1例患者在7个月时死于转移。所有病例的组织病理学检查均显示为高分化至中分化肿瘤。
在高危OSSN病例中使用UBM有助于发现眼内侵犯。眼内侵犯高危肿瘤包括厚的结节型肿瘤（>5 mm）、具有结节或溃疡形态的肿瘤以及既往接受过手术干预的肿瘤。
