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本文引用的文献

1
Recent Advances in Computational Protocols Addressing Intrinsically Disordered Proteins.计算协议的最新进展解决了固有无序蛋白质的问题。
Biomolecules. 2019 Apr 11;9(4):146. doi: 10.3390/biom9040146.
2
Electrostatics of Tau Protein by Molecular Dynamics.tau 蛋白的分子动力学静电势。
Biomolecules. 2019 Mar 23;9(3):116. doi: 10.3390/biom9030116.
3
Spontaneous Switching among Conformational Ensembles in Intrinsically Disordered Proteins.天然无序蛋白质构象集合体中的自发转换。
Biomolecules. 2019 Mar 22;9(3):114. doi: 10.3390/biom9030114.
4
Structure and Functions of Microtubule Associated Proteins Tau and MAP2c: Similarities and Differences.微管相关蛋白 Tau 和 MAP2c 的结构与功能:相似与不同。
Biomolecules. 2019 Mar 16;9(3):105. doi: 10.3390/biom9030105.
5
Role of Phosphorylation in the Modulation of the Glucocorticoid Receptor's Intrinsically Disordered Domain.磷酸化在糖皮质激素受体无规则结构域调节中的作用。
Biomolecules. 2019 Mar 11;9(3):95. doi: 10.3390/biom9030095.
6
Functional Segments on Intrinsically Disordered Regions in Disease-Related Proteins.疾病相关蛋白中无规则区域的功能片段。
Biomolecules. 2019 Mar 5;9(3):88. doi: 10.3390/biom9030088.
7
Conserved Glycines Control Disorder and Function in the Cold-Regulated Protein, COR15A.保守甘氨酸控制冷调节蛋白 COR15A 的构象和功能。
Biomolecules. 2019 Mar 2;9(3):84. doi: 10.3390/biom9030084.
8
p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX.p53 磷酸模拟物保留瞬时二级结构,但减少与 Mdm2 和 MdmX 的结合。
Biomolecules. 2019 Mar 2;9(3):83. doi: 10.3390/biom9030083.
9
Extreme Fuzziness: Direct Interactions between Two IDPs.极端模糊性:两个 IDP 之间的直接相互作用。
Biomolecules. 2019 Feb 26;9(3):81. doi: 10.3390/biom9030081.
10
Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level.无序蛋白的结构与动态有序性:从系统水平看 PAGE4 构象转变的分子机制。
Biomolecules. 2019 Feb 22;9(2):77. doi: 10.3390/biom9020077.

慢性疾病中的无序蛋白质

Intrinsically Disordered Proteins in Chronic Diseases.

机构信息

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

出版信息

Biomolecules. 2019 Apr 11;9(4):147. doi: 10.3390/biom9040147.

DOI:10.3390/biom9040147
PMID:30979084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6523076/
Abstract

t is now increasingly evident that a large fraction of the human proteome comprises proteins that, under physiological conditions, lack fixed, ordered 3D structures as a whole or have segments that are not likely to form a defined 3D structure [...].

摘要

现在越来越明显的是,人类蛋白质组的很大一部分由这样的蛋白质组成,在生理条件下,这些蛋白质整体缺乏固定的、有序的 3D 结构,或者有不形成明确 3D 结构的片段[... ]。