慢性疾病中的无序蛋白质
Intrinsically Disordered Proteins in Chronic Diseases.
机构信息
Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
出版信息
Biomolecules. 2019 Apr 11;9(4):147. doi: 10.3390/biom9040147.
Abstract
t is now increasingly evident that a large fraction of the human proteome comprises proteins that, under physiological conditions, lack fixed, ordered 3D structures as a whole or have segments that are not likely to form a defined 3D structure [...].
摘要
现在越来越明显的是，人类蛋白质组的很大一部分由这样的蛋白质组成，在生理条件下，这些蛋白质整体缺乏固定的、有序的 3D 结构，或者有不形成明确 3D 结构的片段[... ]。
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