Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.
Sci Rep. 2019 Apr 12;9(1):6015. doi: 10.1038/s41598-019-42190-1.
Glucocorticoids (GCs) are critical regulators of metabolic control in mammals and their aberrant function has been linked to several pathologies. GCs are widely used in human and veterinary clinical practice as potent anti-inflammatory and immune suppressive agents. Dyslipidaemia is a frequently observed consequence of GC treatment, typified by increased lipolysis, lipid mobilization, liponeogenesis, and adipogenesis. Dogs with excess GC show hyperlipidaemia, hypertension, and a higher risk of developing type 2 diabetes mellitus, but the risk of developing atherosclerotic lesions is low as compared to humans. This study aimed to examine alterations in the canine plasma lipidome in a model of experimentally induced short-term and long-term GC excess. Both treatments led to significant plasma lipidome alterations, which were more pronounced after long-term excess steroid exposure. In particular, monohexosylceramides, phosphatidylinositols, ether phosphatidylcholines, acyl phosphatidylcholines, triacylglycerols and sphingosine 1-phosphates showed significant changes. The present study highlights the hitherto unknown effects of GCs on lipid metabolism, which will be important in the further elucidation of the role and function of GCs as drugs and in metabolic and cardiovascular diseases.
糖皮质激素（GCs）是哺乳动物代谢调控的关键调节剂，其功能异常与多种病理学有关。GCs 在人类和兽医临床实践中被广泛用作有效的抗炎和免疫抑制剂。脂代谢紊乱是 GC 治疗的常见后果，其特征为脂肪分解、脂质动员、脂肪生成增加。GC 过多的狗表现出高脂血症、高血压和 2 型糖尿病的风险增加，但与人类相比，发生动脉粥样硬化病变的风险较低。本研究旨在检查实验诱导的短期和长期 GC 过量模型中犬血浆脂质组的变化。两种治疗方法均导致显著的血浆脂质组改变，长期过量类固醇暴露后更为明显。特别是单半乳糖神经酰胺、磷脂酰肌醇、醚磷脂酰胆碱、酰基磷脂酰胆碱、三酰甘油和鞘氨醇 1-磷酸显著变化。本研究强调了 GC 对脂质代谢的迄今未知的影响，这对于进一步阐明 GC 作为药物在代谢和心血管疾病中的作用和功能将是重要的。
