Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Surgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Genes (Basel). 2019 Apr 2;10(4):270. doi: 10.3390/genes10040270.
Changes in gut microbiota composition have consistently been observed in patients with colorectal cancer (CRC). Yet, it is not entirely clear how the gut microbiota interacts with tumor cells. We know that tumor cells undergo a drastic change in energy metabolism, mediated by microRNAs (miRNAs), and that tumor-derived miRNAs affect the stromal and immune cell fractions of the tumor microenvironment. Recent studies suggest that host intestinal miRNAs can also affect the growth and composition of the gut microbiota. Our previous CRC studies showed a high-level of interconnectedness between host miRNAs and their microbiota. Considering all the evidence to date, we postulate that the altered nutrient composition and miRNA expression in the CRC microenvironment selectively exerts pressure on the surrounding microbiota, leading to alterations in its composition. In this review article, we present our current understanding of the role of miRNAs in mediating host-microbiota interactions in CRC.
结直肠癌（CRC）患者的肠道微生物组成发生了变化。然而，肠道微生物与肿瘤细胞如何相互作用尚不完全清楚。我们知道，肿瘤细胞的能量代谢发生了剧烈变化，这是由 microRNAs（miRNAs）介导的，而且肿瘤衍生的 miRNAs 会影响肿瘤微环境中的基质和免疫细胞。最近的研究表明，宿主肠道 miRNAs 也可以影响肠道微生物的生长和组成。我们之前的 CRC 研究表明，宿主 miRNAs 与其微生物群之间存在高度的相互关联性。考虑到迄今为止的所有证据，我们假设 CRC 微环境中改变的营养成分和 miRNA 表达选择性地对周围的微生物群施加压力，导致其组成发生改变。在这篇综述文章中，我们介绍了目前对 miRNA 在调节 CRC 中宿主-微生物群相互作用中的作用的理解。
