Dong Jiayi, Tai Jesse W, Lu Li-Fan
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
Trends Cancer. 2019 Nov;5(11):666-669. doi: 10.1016/j.trecan.2019.08.003. Epub 2019 Oct 14.
Gut homeostasis is maintained by dynamic host-microbiota interactions. Recently, miRNAs have emerged as key molecular regulators in the mediation of such interactions. Here, we discuss the role of a host miRNA-microbiome axis in gut homeostasis and colorectal cancer (CRC) and the involvement of diet and microbial metabolites in miRNA-mediated intestinal health.
肠道稳态通过宿主与微生物群的动态相互作用得以维持。近年来，微小RNA（miRNA）已成为介导此类相互作用的关键分子调节因子。在此，我们讨论宿主miRNA-微生物组轴在肠道稳态和结直肠癌（CRC）中的作用，以及饮食和微生物代谢产物在miRNA介导的肠道健康中的作用。
