Naderpoor Negar, Mousa Aya, Gomez-Arango Luisa F, Barrett Helen L, Dekker Nitert Marloes, de Courten Barbora
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Diabetes and Vascular Medicine Unit, Monash Health, Clayton 3168, Australia.
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton 3168, Australia.
J Clin Med. 2019 Apr 4;8(4):452. doi: 10.3390/jcm8040452.
Emerging evidence suggests a role for the gut microbiota in glucose metabolism and diabetes. Few studies have examined the associations between the faecal microbiome and insulin sensitivity and secretion using gold-standard methods in high-risk populations prior to diabetes onset. We investigated the relationships between faecal microbiota composition (16S rRNA sequencing) and gold-standard measures of insulin sensitivity (hyperinsulinaemic-euglycaemic clamp) and insulin secretion (intravenous glucose tolerance test) in 38 overweight or obese otherwise healthy individuals. Genus was positively associated with insulin sensitivity, and genera and were related to both insulin sensitivity and secretion. Insulin sensitivity was associated with a higher abundance of and lower abundance of . Those with higher insulin secretion had a higher abundance of and lower abundance of , compared to those with lower insulin secretion. Body mass index (BMI) was positively correlated with abundance whereas abundance was negatively correlated to BMI and percent body fat. These results suggest that faecal microbiota is related to insulin sensitivity and secretion in overweight or obese adults. These correlations are distinct although partially overlapping, suggesting different pathophysiological pathways. Our findings can inform future trials aiming to manipulate gut microbiome to improve insulin sensitivity and secretion and prevent type 2 diabetes.
新出现的证据表明肠道微生物群在葡萄糖代谢和糖尿病中发挥作用。很少有研究在糖尿病发病前使用金标准方法研究高危人群中粪便微生物群与胰岛素敏感性和分泌之间的关联。我们调查了38名超重或肥胖但其他方面健康的个体中粪便微生物群组成（16S rRNA测序）与胰岛素敏感性（高胰岛素-正常血糖钳夹）和胰岛素分泌（静脉葡萄糖耐量试验）的金标准测量之间的关系。属与胰岛素敏感性呈正相关，属和属与胰岛素敏感性和分泌均有关。胰岛素敏感性与较高的丰度和较低的丰度相关。与胰岛素分泌较低的人相比，胰岛素分泌较高的人具有较高的丰度和较低的丰度。体重指数（BMI）与丰度呈正相关，而丰度与BMI和体脂百分比呈负相关。这些结果表明，粪便微生物群与超重或肥胖成年人的胰岛素敏感性和分泌有关。这些相关性是不同的，尽管部分重叠，表明存在不同的病理生理途径。我们的发现可为未来旨在操纵肠道微生物群以改善胰岛素敏感性和分泌并预防2型糖尿病的试验提供参考。
