Ai Su, Tang Wei, Guo Ruo-Lin, Li Ji-Qian, Yang Wu, He Zeng-Guo
School of Medicine and Pharmacy,Ocean University of China Qingdao 266003,China.
School of Medicine and Pharmacy,Ocean University of China Qingdao 266003,China Marine Microbiological Engineering & Research Center,Marine Biomedical Research Institute of Qingdao Qingdao 266100,China.
Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(6):1110-1118. doi: 10.19540/j.cnki.cjcmm.20181227.002.
Chinese herbal medicines( CHMs) are a class of preparations made from natural plants that pose health beneficial properties as well as illness prevention functions. Thanks to a panel of salutary features,such as comprehensive immunological enhancement and inhibition of pathogenic bacteria,negligible side-effects,inappreciable drug-resistance,CHMs have been taken as one of the costeffective candidates for antibiotics substitutions. Through probiotics fermentation,the enzymatic hydrolysis of matrixes of CHMs enables easier release of the active ingredient as well as endows less toxicity of the preparations derived. During fermentation,the macromolecule or polymers forms of the active ingredient can be cut down to smaller molecule,which favors the transmembrane transport and improve adsorption of the active ingredients by the tissues. Other than the enzymatic benefits,probiotics can produce metabolites that inhibit pathogenic bacteria propagation,which may function synergically with the inhibitory effects of the CHMs preparations to fight the target pathogens. In addition,the oligosaccharide like components of CHMs can promote the growth of probiotics in intestinal environment which may largely facilitate the gut health. To summarize,the fermentation of CHMs using probiotics brings about the biochemical reactions and elevates the health beneficial effects by synergy of the microbial and herbal activities. It has been proved to be one of promising approaches as to antibiotic substitutions,particularly in livestock and poultry breeding industries. This review covered the recent progress of CHMs fermentation on the aspects of microbial strains,patterns of fermentation and active substances from fermentation of CHMs and their potency,respectively.
中草药是一类由天然植物制成的制剂，具有有益健康和预防疾病的功能。由于具有一系列有益特性，如全面增强免疫力、抑制病原菌、副作用可忽略不计、耐药性不明显等，中草药已被视为抗生素替代的经济有效选择之一。通过益生菌发酵，中草药基质的酶解作用能使活性成分更易释放，并降低所得制剂的毒性。发酵过程中，活性成分的大分子或聚合物形式可被分解为更小的分子，这有利于跨膜转运并提高组织对活性成分的吸附。除了酶解益处外，益生菌可产生抑制病原菌繁殖的代谢产物，这些代谢产物可能与中草药制剂的抑制作用协同对抗目标病原体。此外，中草药中的低聚糖样成分可促进肠道环境中益生菌的生长，这可能极大地促进肠道健康。总之，利用益生菌对中草药进行发酵会引发生化反应，并通过微生物和草药活性的协同作用提高有益健康的效果。事实证明，这是抗生素替代的一种有前景的方法，尤其在畜禽养殖业中。本综述分别涵盖了中草药发酵在微生物菌株、发酵模式以及发酵产生的活性物质及其功效等方面的最新进展。
