Brain Imaging Centre, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest H-1117, Hungary.
Brain Imaging Centre, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest H-1117, Hungary.
Neuroimage Clin. 2019;23:101803. doi: 10.1016/j.nicl.2019.101803. Epub 2019 Mar 27.
Increased fMRI food cue reactivity in obesity, i.e. higher responses to high- vs. low-calorie food images, is a promising marker of the dysregulated brain reward system underlying enhanced susceptibility to obesogenic environmental cues. Recently, it has also been shown that weight loss interventions might affect fMRI food cue reactivity and that there is a close association between the alteration of cue reactivity and the outcome of the intervention. Here we tested whether fMRI food cue reactivity could be used as a marker of diet-induced early changes of neural processing in the striatum that are predictive of the outcome of the weight loss intervention. To this end we investigated the relationship between food cue reactivity in the striatum measured one month after the onset of the weight loss program and weight changes obtained at the end of the six-month intervention. We observed a significant correlation between BMI change measured after six months and early alterations of fMRI food cue reactivity in the striatum, including the bilateral putamen, right pallidum, and left caudate. Our findings provide evidence for diet-induced early alterations of fMRI food cue reactivity in the striatum that can predict the outcome of the weight loss intervention.
在肥胖症中，功能性磁共振成像（fMRI）食物线索反应增强，即对高卡路里与低卡路里食物图像的反应更高，这是大脑奖励系统失调的一个有前途的标志物，这种失调系统使人们更容易受到肥胖环境线索的影响。最近，人们还发现，减肥干预措施可能会影响 fMRI 食物线索反应，并且线索反应的改变与干预的结果密切相关。在这里，我们测试了 fMRI 食物线索反应是否可以作为预测减肥干预结果的纹状体神经加工早期变化的标志物。为此，我们研究了在减肥计划开始一个月后测量的纹状体中的食物线索反应与六个月干预结束时获得的体重变化之间的关系。我们发现，在六个月后测量的 BMI 变化与纹状体中 fMRI 食物线索反应的早期改变之间存在显著相关性，包括双侧壳核、右侧苍白球和左侧尾状核。我们的发现为纹状体中 fMRI 食物线索反应的饮食诱导早期改变提供了证据，这些改变可以预测减肥干预的结果。
