Department of Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Clinics (Sao Paulo). 2019 Apr 8;74:e890. doi: 10.6061/clinics/2019/e890.
We aimed to explore the effects of diet on the inflammatory response in middle-aged and elderly people with hypertension.
Thirty overweight or obese patients with stage one hypertension (age range, 45-75 years) were allocated to either the intervention or control group (n=15 per group; age- and sex-matched). Patients in the intervention group consumed a food powder supplement (100 g) instead of a regular meal. The control group maintained their normal dietary habits. This study lasted for six weeks. Blood pressure, inflammatory marker levels, and energy intake were measured before and after the study.
After 6 weeks, the diet composition of the intervention group changed significantly (p<0.05). The intake of proteins, dietary fibre, monounsaturated fat, and polyunsaturated fat increased significantly (p<0.05), while the total energy intake trended towards an increase (p>0.05). In the control group, the total energy intake decreased significantly (p<0.05). The levels of nuclear factor-κB (NF-κB), soluble intercellular adhesion molecule-1 (sICAM-1) and high sensitivity C-reactive protein (hs-CRP) decreased, and adiponectin increased significantly in the intervention group (p<0.05); however, no significant changes were observed in the inflammatory marker levels of the control group. In the intervention group, systolic blood pressure decreased significantly (p<0.05), and diastolic blood pressure also exhibited a decreasing trend. No significant change in blood pressure was observed in the control group.
The consumption of a food powder supplement can improve diet composition, decrease blood pressure and reduce inflammation in middle-aged and elderly overweight or obese hypertensive patients. The food powder supplement may also have an anti-atherosclerotic effect in hypertensive patients.
探讨饮食对中老年高血压患者炎症反应的影响。
将 30 名超重或肥胖的 1 期高血压患者（年龄 45-75 岁）分为干预组和对照组（每组 15 名；年龄和性别匹配）。干预组患者食用食物粉补充剂（100 g）代替常规餐。对照组保持正常饮食。研究持续 6 周。分别在研究前后测量血压、炎症标志物水平和能量摄入。
6 周后，干预组的饮食结构发生明显变化（p<0.05）。蛋白质、膳食纤维、单不饱和脂肪和多不饱和脂肪的摄入量明显增加（p<0.05），而总能量摄入量呈增加趋势（p>0.05）。对照组总能量摄入明显减少（p<0.05）。干预组核因子-κB（NF-κB）、可溶性细胞间黏附分子-1（sICAM-1）和高敏 C 反应蛋白（hs-CRP）水平降低，脂联素水平升高（p<0.05）；对照组炎症标志物水平无明显变化。干预组收缩压明显下降（p<0.05），舒张压也呈下降趋势。对照组血压无明显变化。
食用食物粉补充剂可以改善饮食结构，降低中老年超重或肥胖高血压患者的血压和炎症水平。食物粉补充剂对高血压患者可能具有抗动脉粥样硬化作用。
