Vieira-Gonçalves Ricardo, Fagundes-Silva Giselle Aparecida, Heringer Júlia Furtado, Fantinatti Maria, Da-Cruz Alda Maria, Oliveira-Neto Manoel Paes, Guerra Jorge Augusto Oliveira, Gomes-Silva Adriano
Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Infectologia Evandro Chagas, FIOCRUZ, Rio de Janeiro, RJ, Brasil.
Rev Soc Bras Med Trop. 2019 Apr 11;52:e20180323. doi: 10.1590/0037-8682-0323-2018.
We report the case of a 32-year-old man from Rio de Janeiro, who was infected in the Amazon region of Brazil by Leishmania (Viannia) naiffi. Generally, patients with L. naiffi cutaneous leishmaniasis exhibit a good therapeutic response to either pentavalent antimonials or pentamidine. However, after pentamidine treatment, this patient's infection evolved to therapeutic failure. To understand this clinical outcome, we investigated the presence of the Leishmania RNA virus (LRV) in parasites isolated from the cutaneous lesion; herein, we discuss the possible association between a poor response to pentamidine therapy and the presence of the LRV.
我们报告了一名来自里约热内卢的32岁男子的病例，他在巴西亚马逊地区感染了圭亚那利什曼原虫（维安尼亚利什曼原虫亚属）。一般来说，感染圭亚那利什曼原虫的皮肤利什曼病患者对五价锑剂或喷他脒均表现出良好的治疗反应。然而，在接受喷他脒治疗后，该患者的感染发展为治疗失败。为了解这一临床结果，我们调查了从皮肤病变中分离出的寄生虫中利什曼原虫RNA病毒（LRV）的存在情况；在此，我们讨论了喷他脒治疗反应不佳与LRV存在之间的可能关联。
