利什曼病毒的遗传多样性与利什曼病治疗失败无关。
Leishmaniavirus genetic diversity is not related to leishmaniasis treatment failure.
机构信息
Ecosystemes Amazoniens et Pathologie Tropicale - EA 3593 - Labex CEBA - Medicine Department, University of French Guiana, Cayenne, French Guiana; Laboratoire Associé - Centre National de Référence Leishmania, Laboratory of Parasitology and Mycology, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.
Ecosystemes Amazoniens et Pathologie Tropicale - EA 3593 - Labex CEBA - Medicine Department, University of French Guiana, Cayenne, French Guiana; Guianan Institute of Tropical Dermatology, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.
出版信息
Clin Microbiol Infect. 2021 Feb;27(2):286.e1-286.e5. doi: 10.1016/j.cmi.2020.04.037. Epub 2020 May 4.
OBJECTIVES
The outcome of American tegumentary leishmaniasis (ATL) may depend on the presence of the Leishmania RNA virus (LRV). This virus may be involved in treatment failure. We aimed to determine whether genetic clusters of LRV1 are involved in this therapeutic outcome.
METHODS
The presence of LRV1 was assessed in 129 Leishmania guyanensis isolates from patients treated with pentamidine in French Guiana. Among the 115 (89%) isolates found to carry LRV1, 96 were successfully genotyped. Patient clinical data were linked to the LRV data.
RESULTS
The rate of treatment failure for LRV1-positive isolates was 37% (15/41) versus 40% (2/5) among LRV1-negative isolates (p 0.88). Concerning LRV1 genotypes, two predominant LRV1 groups emerged, groups A (23% (22/96)) and B (70% (67/96)). The treatment failure rate was 37% (3/8) for group A and 45% (9/20) for group B (p 0.31).
DISCUSSION
Neither the presence nor genotype of LRV1 in patients with L. guyanensis seemed to correlate with pentamidine treatment failure.
目的
美国皮肤利什曼病（ATL）的结局可能取决于利什曼 RNA 病毒（LRV）的存在。这种病毒可能与治疗失败有关。我们旨在确定 LRV1 的遗传簇是否与这种治疗结果有关。
方法
在法属圭亚那用戊烷脒治疗的 129 株利什曼原虫圭亚那株中评估了 LRV1 的存在。在发现携带 LRV1 的 115 株（89%）分离株中，有 96 株成功进行了基因分型。将患者的临床数据与 LRV 数据相关联。
结果
LRV1 阳性分离株的治疗失败率为 37%（15/41），LRV1 阴性分离株为 40%（2/5）（p 0.88）。关于 LRV1 基因型，出现了两个主要的 LRV1 组，A 组（23%（22/96））和 B 组（70%（67/96））。A 组的治疗失败率为 37%（3/8），B 组为 45%（9/20）（p 0.31）。
讨论
LRV1 在携带 L. 圭亚那利什曼原虫的患者中的存在或基因型似乎都与戊烷脒治疗失败无关。
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