Grenci Gianluca, Bertocchi Cristina, Ravasio Andrea
Mechanobiology Institute (MBI), National University of Singapore, Singapore 117411, Singapore.
Biomedical Engineering Department, National University of Singapore, Singapore 117583, Singapore.
Micromachines (Basel). 2019 Apr 16;10(4):252. doi: 10.3390/mi10040252.
The advent of micro and nanotechnologies, such as microfabrication, have impacted scientific research and contributed to meaningful real-world applications, to a degree seen during historic technological revolutions. Some key areas benefitting from the invention and advancement of microfabrication platforms are those of biological and biomedical sciences. Modern therapeutic approaches, involving point-of-care, precision or personalized medicine, are transitioning from the experimental phase to becoming the standard of care. At the same time, biological research benefits from the contribution of microfluidics at every level from single cell to tissue engineering and organoids studies. The aim of this commentary is to describe, through proven examples, the interdisciplinary process used to develop novel biological technologies and to emphasize the role of technical knowledge in empowering researchers who are specialized in a niche area to look beyond and innovate.
微纳技术的出现，如微制造技术，已经对科学研究产生了影响，并促成了有意义的实际应用，其影响程度堪比历史上的技术革命。受益于微制造平台的发明与进步的一些关键领域是生物科学和生物医学科学领域。涉及即时护理、精准或个性化医疗的现代治疗方法正在从实验阶段过渡到成为护理标准。与此同时，生物学研究在从单细胞到组织工程和类器官研究的各个层面都受益于微流控技术的贡献。本评论的目的是通过已证实的例子来描述用于开发新型生物技术的跨学科过程，并强调技术知识在使专注于特定领域的研究人员拓宽视野并进行创新方面所起的作用。
