Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Nat Biomed Eng. 2018 Sep;2(9):640-648. doi: 10.1038/s41551-018-0288-9. Epub 2018 Sep 11.
Point-of-care sensors that enable the fast collection of information relevant to a patient's health state can facilitate improved health access, reduce healthcare costs and improve the quality of healthcare delivery. In the diagnosis of sepsis - defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, and the leading cause of in-patient death and of hospital readmission in the United States - predicting which infections will lead to life-threatening organ dysfunction and developing specific anti-sepsis treatments remain challenging because of the significant heterogeneity of the host response. Yet the use of point-of-care devices could reduce the time from the onset of a patient's infection to the administration of appropriate therapeutics. In this Perspective, we describe the current state of point-of-care sensors for the diagnosis and monitoring of sepsis, and outline opportunities in the use of these devices to dramatically improve patient care.
即时检测传感器可以快速收集与患者健康状况相关的信息，有助于改善医疗服务的可及性，降低医疗成本，并提高医疗服务质量。在脓毒症的诊断中 - 脓毒症是指由宿主对感染的失调反应引起的危及生命的器官功能障碍，是美国住院患者死亡和再次住院的主要原因 - 预测哪些感染会导致危及生命的器官功能障碍并开发特定的抗脓毒症治疗方法仍然具有挑战性，因为宿主反应存在显著的异质性。然而，即时检测设备的使用可以减少从患者感染开始到给予适当治疗的时间。在本观点中，我们描述了即时检测传感器在脓毒症诊断和监测中的现状，并概述了使用这些设备来显著改善患者护理的机会。
