口服劳拉西泮与地西泮在口腔颌面外科镇静中的对比研究
Comparative Study Between Oral Lorazepam and Diazepam as Sedation in Oral and Maxillofacial Surgery.
作者信息
Sharma Vikas, Singh Amaninder, Sharma Parul, Kaur Simranjeet, Zutshi Akanksha
机构信息
1Oral and Maxillofacial Surgery, National Dental College, Derabassi, Punjab India.
Panchkula, Haryana India.
出版信息
J Maxillofac Oral Surg. 2019 Jun;18(2):256-259. doi: 10.1007/s12663-018-1096-1. Epub 2018 Mar 5.
PURPOSE
The aim of the study was to compare the efficacy of oral lorazepam as night sedation and premedication with diazepam.
METHODS
A prospective, randomized, and double-blind study was done in 50 healthy patients in each drug group. The impacted third molar impaction was taken as the study model. Study was carried out after giving bioequivalent doses of respective drugs for either side. All the patients were assessed for quality of sleep, sedation, recall of visual stimuli, cooperation shown by patient and recovery postoperatively.
RESULTS
The study concluded that lorazepam showed more advantages than diazepam as well as patient's preference and satisfaction. However, postoperative recovery with lorazepam was longer than diazepam.
目的
本研究的目的是比较口服劳拉西泮作为夜间镇静剂和地西泮作为术前用药的疗效。
方法
在每个药物组中对50名健康患者进行了一项前瞻性、随机、双盲研究。将阻生第三磨牙阻生作为研究模型。在给予两侧各自药物的生物等效剂量后进行研究。对所有患者的睡眠质量、镇静程度、视觉刺激回忆、患者表现出的合作程度以及术后恢复情况进行评估。
结果
研究得出结论，劳拉西泮比地西泮显示出更多优势，以及患者的偏好和满意度。然而，劳拉西泮术后恢复时间比地西泮长。
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