Gupta Mrinali P, Yonekawa Yoshihiro, Campbell J Peter, Rusu Irene, Zahid Sarwar, Patel Samir N, Chau Felix, Jonas Karyn E, Oltra Erica, Orlin Anton, Chang Jonathan, Horowitz Jason, Abramson David H, Marr Brian, Capone Antonio, Paul Chan R V
Ophthalmic Surg Lasers Imaging Retina. 2019 Apr 1;50(4):201-207. doi: 10.3928/23258160-20190401-01.
Aggressive posterior vitreoretinopathy (APVR) manifests with a broad area of retinal avascularity, progressive neovascularization, and/or tractional retinal detachment during the neonatal period.
A multicenter, retrospective, observational, consecutive case series study was performed to evaluate the retinal findings and structural retinal outcomes in patients treated for APVR within the first 3 months of life.
Three premature neonates with a non-retinopathy of prematurity (ROP) APVR identified during routine ROP screening exams exhibited relatively severe, rapidly progressive retinal vascular abnormalities. Immediate laser photocoagulation of the avascular retina and vitrectomy for traction retinal detachment within several days to weeks improved or stabilized the retinal anatomy in all cases.
This series describes clinical features in APVR in premature infants and suggests that early diagnosis and intervention may mitigate the typical aggressive course and poor prognosis of this condition. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:201-207.].
侵袭性后部玻璃体视网膜病变（APVR）在新生儿期表现为广泛的视网膜无血管区、进行性新生血管形成和/或牵拉性视网膜脱离。
进行了一项多中心、回顾性、观察性、连续病例系列研究，以评估在出生后前3个月接受APVR治疗的患者的视网膜检查结果和视网膜结构转归。
在常规视网膜病变筛查检查中确诊的3例无早产儿视网膜病变（ROP）的APVR早产儿表现出相对严重、进展迅速的视网膜血管异常。在数天至数周内对无血管视网膜立即进行激光光凝，并对牵拉性视网膜脱离进行玻璃体切除术，所有病例的视网膜解剖结构均得到改善或稳定。
本系列描述了早产儿APVR的临床特征，并表明早期诊断和干预可能减轻该病典型的侵袭性病程和不良预后。[《眼科手术、激光与影像学杂志》2019年；50:201 - 207。]
