1,2,4-三唑衍生物的抗菌活性研究。
Antibacterial activity study of 1,2,4-triazole derivatives.
机构信息
State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, PR China; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, PR China.
State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China.
出版信息
Eur J Med Chem. 2019 Jul 1;173:274-281. doi: 10.1016/j.ejmech.2019.04.043. Epub 2019 Apr 16.
Antibiotics are commonly used to fight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. 1,2,4-Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. Hybridization displays a high potential to develop novel drugs with the capacity to overcome drug resistance, reduce toxicity and improve pharmacokinetic profiles. More effective antibacterial candidates might be obtained by the hybridization of 1,2,4-triazole with other antibacterial pharmacophores. This review summarizes the recent advances of 1,2,4-triazole derivatives as potential antibacterial compounds, and the structure-activity relationship is also discussed.
抗生素通常用于对抗细菌感染，但由于抗生素的滥用，细菌已经对几乎所有抗生素产生了耐药性。1,2,4-三唑衍生化合物具有化学治疗效果，包括对药敏和耐药病原体的潜在抗菌活性。杂交显示出开发具有克服耐药性、降低毒性和改善药代动力学特性的新型药物的巨大潜力。通过将 1,2,4-三唑与其他抗菌药效团杂交，可以获得更有效的抗菌候选物。本综述总结了 1,2,4-三唑衍生物作为潜在抗菌化合物的最新进展，并讨论了结构-活性关系。
Zotero 插件