Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Viruses. 2019 Apr 22;11(4):369. doi: 10.3390/v11040369.
Papillomaviruses replicate and cause disease in stratified squamous epithelia. Epithelial differentiation is essential for the progression of papillomavirus replication, but differentiation is also impaired by papillomavirus-encoded proteins. The papillomavirus E6 and E7 oncoproteins partially inhibit and/or delay epithelial differentiation and some of the mechanisms by which they do so are beginning to be defined. This review will outline the key features of the relationship between HPV infection and differentiation and will summarize the data indicating that papillomaviruses alter epithelial differentiation. It will describe what is known so far and will highlight open questions about the differentiation-inhibitory mechanisms employed by the papillomaviruses.
乳头瘤病毒在复层鳞状上皮中复制并引起疾病。上皮分化对于乳头瘤病毒复制的进展至关重要，但乳头瘤病毒编码的蛋白也会损害分化。乳头瘤病毒 E6 和 E7 癌蛋白部分抑制和/或延迟上皮分化，它们这样做的一些机制开始被定义。这篇综述将概述 HPV 感染与分化之间的关系的关键特征，并总结表明乳头瘤病毒改变上皮分化的数据。它将描述到目前为止已知的内容，并强调关于乳头瘤病毒使用的分化抑制机制的悬而未决的问题。
