Becker H, Schauer U, Helmke K
Clin Exp Immunol. 1986 Nov;66(2):365-72.
In order to study the capacity of anti-immunoglobulin (Ig) antibodies to induce proliferative responses in peripheral blood mononuclear cells (PBC) from patients with systemic lupus erythematosus (SLE), anti-mu coupled to Sepharose beads (anti-mu) was used as a polyclonal activator. In 18 patients, a strong proliferative response was associated with inactive disease, and the response was lower in clinical active disease (P less than 0.02). An inverse correlation could also be observed in six patients who were studied longitudinally (P less than 0.01). These results indicate that anti-mu responsiveness is closely related to disease activity in SLE. In addition, sequential data obtained from two patients during an early stage of clinical deterioration suggest that a low anti-mu response might be an early indicator of a clinical relapse. In the patients investigated, the anti-mu response was not correlated with the response to pokeweed mitogen (PWM), or with the quantity of B cells. When T cell depleted cell fractions were studied, marked increases in the proliferative responses to anti-mu were observed in some patients. These studies suggest that the response to anti-mu might be modified by T cells to a variable extent in patients with SLE.
为了研究抗免疫球蛋白（Ig）抗体诱导系统性红斑狼疮（SLE）患者外周血单个核细胞（PBC）增殖反应的能力，将偶联至琼脂糖珠的抗μ（抗μ）用作多克隆激活剂。在18例患者中，强烈的增殖反应与疾病非活动期相关，而在临床活动期反应较低（P<0.02）。在6例纵向研究的患者中也观察到负相关（P<0.01）。这些结果表明，抗μ反应性与SLE的疾病活动密切相关。此外，从两名处于临床恶化早期阶段的患者获得的连续数据表明，抗μ反应低可能是临床复发的早期指标。在所研究的患者中，抗μ反应与对商陆有丝分裂原（PWM）的反应或B细胞数量无关。当研究去除T细胞的细胞组分时，在一些患者中观察到对抗μ的增殖反应明显增加。这些研究表明，在SLE患者中，T细胞可能在不同程度上改变对抗μ的反应。
