Casado Javier G, Blázquez Rebeca, Vela Francisco Javier, Álvarez Verónica, Tarazona Raquel, Sánchez-Margallo Francisco Miguel
Stem Cell Therapy Unit, "Jesús Usón" Minimally Invasive Surgery Centre, Cáceres, Spain; Immunology Unit, Department of Physiology, University of Extremadura, Cáceres, Spain; CIBER de Enfermedades Cardiovasculares, Cáceres, Spain.
Stem Cell Therapy Unit, "Jesús Usón" Minimally Invasive Surgery Centre, Cáceres, Spain; CIBER de Enfermedades Cardiovasculares, Cáceres, Spain.
Front Vet Sci. 2017 Mar 21;4:39. doi: 10.3389/fvets.2017.00039. eCollection 2017.
Synovitis is an inflammatory process associated with pain, disability, and discomfort, which is usually treated with anti-inflammatory drugs or biological agents. Mesenchymal stem cells (MSCs) have been also successfully used in the treatment of inflammatory-related diseases such as synovitis or arthritis. In the last years, the exosomes derived from MSCs have become a promising tool for the treatment of inflammatory-related diseases and their therapeutic effect is thought to be mediated (at least in part) by their immunomodulatory potential. In this work, we aimed to evaluate the anti-inflammatory effect of these exosomes in an antigen-induced synovitis animal model. To our knowledge, this is the first report where exosomes derived from MSCs have been evaluated in an animal model of synovitis. Our results demonstrated a decrease of synovial lymphocytes together with a downregulation of TNF-α transcripts in those exosome-treated joints. These results support the immunomodulatory effect of these exosomes and point out that they may represent a promising therapeutic option for the treatment of synovitis.
滑膜炎是一种与疼痛、功能障碍和不适相关的炎症过程，通常用抗炎药物或生物制剂进行治疗。间充质干细胞（MSCs）也已成功用于治疗诸如滑膜炎或关节炎等炎症相关疾病。在过去几年中，源自间充质干细胞的外泌体已成为治疗炎症相关疾病的一种有前景的工具，并且其治疗效果被认为（至少部分）是由其免疫调节潜能介导的。在这项工作中，我们旨在评估这些外泌体在抗原诱导的滑膜炎动物模型中的抗炎作用。据我们所知，这是首次在滑膜炎动物模型中评估源自间充质干细胞的外泌体的报告。我们的结果表明，在那些接受外泌体治疗的关节中，滑膜淋巴细胞减少，同时TNF-α转录物下调。这些结果支持了这些外泌体的免疫调节作用，并指出它们可能代表治疗滑膜炎的一种有前景的治疗选择。
