Monteiro Valter Vinícius Silva, Navegantes-Lima Kely Campos, de Lemos Alessandra Bittencourt, da Silva Guilherme Liberato, de Souza Gomes Rafaelli, Reis Jordano Ferreira, Rodrigues Junior Luiz Carlos, da Silva Onilda Santos, Romão Pedro Roosevelt Torres, Monteiro Marta Chagas
Laboratory of Inflammation and Pain, Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Graduate Program in Neuroscience and Cellular Biology, Biology Science Institute, Federal University of Pará, Belém, Brazil.
Front Microbiol. 2019 Apr 9;10:492. doi: 10.3389/fmicb.2019.00492. eCollection 2019.
mosquitoes are important vectors for emerging diseases caused by arboviruses, such as chikungunya (CHIKV). These viruses' main transmitting species are and , which are present in tropical and temperate climatic areas all over the globe. Knowledge of vector characteristics is fundamentally important to the understanding of virus transmission. Only female mosquitoes are able to transmit CHIKV to the vertebrate host since they are hematophagous. In addition, mosquito microbiota is fundamentally important to virus infection in the mosquito. Microorganisms are able to modulate viral transmission in the mosquito, such as bacteria of the genus, which are capable of preventing viral infection, or protozoans of the species, which are capable of facilitating virus transmission between mosquitoes and larvae. The competence of the mosquito is also important in the transmission of the virus to the vertebrate host, since their saliva has several substances with biological effects, such as immunomodulators and anticoagulants, which are able to modulate the host's response to the virus, interfering in its pathogenicity and virulence. Understanding the vector-chikungunya interaction is fundamentally important since it can enable the search for new methods of combating the virus' transmission.
蚊子是由虫媒病毒引起的新发疾病的重要传播媒介，如基孔肯雅病毒（CHIKV）。这些病毒的主要传播物种是 和 ，它们存在于全球热带和温带气候地区。了解传播媒介的特征对于理解病毒传播至关重要。只有雌蚊能够将基孔肯雅病毒传播给脊椎动物宿主，因为它们是吸血性的。此外，蚊子的微生物群对蚊子体内的病毒感染至关重要。微生物能够调节蚊子体内的病毒传播，例如 属的细菌能够预防病毒感染，或者 种的原生动物能够促进病毒在蚊子和幼虫之间的传播。蚊子的传播能力在将病毒传播给脊椎动物宿主方面也很重要，因为它们的唾液含有几种具有生物学效应的物质，如免疫调节剂和抗凝剂，这些物质能够调节宿主对病毒的反应，干扰其致病性和毒力。了解 传播媒介与基孔肯雅病毒的相互作用至关重要，因为它能够促使人们寻找对抗病毒传播的新方法。
