Faculty of Sport Sciences , Waseda University , Tokorozawa, Saitama, Japan.
J Sports Sci Med. 2013 Sep 1;12(3):571-8. eCollection 2013.
Oxidative stress increases with advancing age and is a mediator of several diseases including cancer, cardiovascular disease, and diabetes. Moreover, postmenopausal women have a lower estrogen concentration, which is associated with elevated oxidative stress. However, there is no definitive evidence regarding the relationship between daily physical activity and oxidative stress status in older adults, including postmenopausal women. Twenty-nine adults (age, 70.1 ± 1.0 years, mean ± SE; 12 women and 17 men) were examined in this cross-sectional study. Prior to blood collection, the participants were asked to wear a uniaxial accelerometer for 4 consecutive weeks to determine their level of physical activity. After a 48-h period of physical activity avoidance and a 10-h overnight fast, venous blood samples were obtained from each participant. Fasting plasma derivatives of reactive oxygen metabolites (d-ROMs) and malondialdehyde (MDA) concentrations of oxidative stress markers were negatively correlated with the amount of physical activity in women (d-ROMs; r = -0.708, p = 0.002) (MDA; r = -0.549, p = 0. 028), but not in men. Fasting plasma biological antioxidant potential of antioxidant capacity marker was positively correlated with the amount of physical activity in women (BAP; r = 0.657, p = 0.006) (GSH; r = 0.549, p = 0.028), but not in men. Moreover, superoxide dismutase activity of antioxidant capacity marker was positively correlated with the amount of physical activity in men (r = 0.627, p = 0.039), but not in women. There were no associations between physical activity and other oxidative stress markers (reduced and oxidized glutathione, glutathione peroxidise, thioredoxin). These findings suggest that regular physical activity may have a protective effect against oxidative stress by increasing total antioxidant capacity, especially in postmenopausal women. Key PointsIt is important to consider daily physical activity status when evaluating antioxidant capacity.Sex differences affect the alteration of oxidative stress markers induced by daily physical activity.Regular physical activity may have a protective effect against oxidative stress by increasing total antioxidant capacity, especially in postmenopausal women.
氧化应激随着年龄的增长而增加，是包括癌症、心血管疾病和糖尿病在内的多种疾病的中介。此外，绝经后妇女的雌激素浓度较低，这与氧化应激升高有关。然而，关于老年人（包括绝经后妇女）的日常体力活动与氧化应激状态之间的关系，尚无明确证据。在这项横断面研究中，检查了 29 名成年人（年龄 70.1 ± 1.0 岁，平均值 ± SE；12 名女性和 17 名男性）。在采集血液之前，参与者被要求佩戴单轴加速度计连续 4 周以确定他们的体力活动水平。在避免 48 小时的体力活动和 10 小时的夜间禁食后，从每个参与者中抽取静脉血样。氧化应激标志物的空腹血浆衍生的活性氧代谢物（d-ROMs）和丙二醛（MDA）浓度与女性的体力活动量呈负相关（d-ROMs；r = -0.708，p = 0.002）（MDA；r = -0.549，p = 0.028），但与男性无关。抗氧化能力标志物的空腹血浆生物抗氧化潜力（BAP）与女性的体力活动量呈正相关（BAP；r = 0.657，p = 0.006）（GSH；r = 0.549，p = 0.028），但与男性无关。此外，抗氧化能力标志物的超氧化物歧化酶活性与男性的体力活动量呈正相关（r = 0.627，p = 0.039），但与女性无关。体力活动与其他氧化应激标志物（还原型和氧化型谷胱甘肽、谷胱甘肽过氧化物酶、硫氧还蛋白）之间没有关联。这些发现表明，通过增加总抗氧化能力，定期体力活动可能对氧化应激具有保护作用，特别是在绝经后妇女中。关键点：评估抗氧化能力时，应考虑日常体力活动状况。性别差异会影响日常体力活动引起的氧化应激标志物的改变。定期体力活动可能通过增加总抗氧化能力对氧化应激具有保护作用，特别是在绝经后妇女中。
