非编码RNA在肺癌肿瘤发生中的作用
The Function of Non-Coding RNAs in Lung Cancer Tumorigenesis.
作者信息
Braicu Cornelia, Zimta Alina-Andreea, Harangus Antonia, Iurca Ioana, Irimie Alexandru, Coza Ovidiu, Berindan-Neagoe Ioana
机构信息
Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, Romania.
MEDFUTURE-Research Center for Advanced Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, Romania.
出版信息
Cancers (Basel). 2019 Apr 30;11(5):605. doi: 10.3390/cancers11050605.
Lung cancer is the most prevalent and deadliest cancer worldwide. A significant part of lung cancer studies is dedicated to the expression alterations of non-coding RNAs. The non-coding RNAs are transcripts that cannot be translated into proteins. While the study of microRNAs and siRNAs in lung cancer received a lot of attention over the last decade, highly efficient therapeutic option or the diagnostic methods based on non-coding RNAs are still lacking. Because of this, it is of utmost importance to direct future research on lung cancer towards analyzing other RNA types for which the currently available data indicates that are essential at modulating lung tumorigenesis. Through our review of studies on this subject, we identify the following non-coding RNAs as tumor suppressors: ts-46, ts-47, ts-101, ts-53, ts-3676, ts-4521 (tRNA fragments), SNORD116-26, HBII-420, SNORD15A, SNORA42 (snoRNAs), piRNA-like-163, piR-35127, the piR-46545 (piRNAs), CHIAP2, LOC100420907, RPL13AP17 (pseudogenes), and uc.454 (T-UCR). We also found non-coding RNAs with tumor-promoting function: tRF-Leu-CAG, tRNA-Leu, tRNA-Val (tRNA fragments), circ-RAD23B, circRNA 100146, circPVT1, circFGFR3, circ_0004015, circPUM1, circFLI1, circABCB10, circHIPK3 (circRNAs), SNORA42, SNORA3, SNORD46, SNORA21, SNORD28, SNORA47, SNORD66, SNORA68, SNORA78 (snoRNAs), piR-65, piR-34871, piR-52200, piR651 (piRNAs), hY4 5' fragments (YRNAs), FAM83A-AS1, WRAP53, NKX2-1-AS1 (NATs), DUXAP8, SFTA1P (pseudogene transcripts), uc.338, uc.339 (T-UCRs), and hTERC.
肺癌是全球最常见且最致命的癌症。肺癌研究的很大一部分致力于非编码RNA的表达改变。非编码RNA是无法翻译成蛋白质的转录本。尽管在过去十年中，肺癌中微小RNA和小干扰RNA的研究受到了广泛关注，但基于非编码RNA的高效治疗方案或诊断方法仍然缺乏。因此，将未来肺癌研究方向转向分析其他RNA类型至关重要，目前可得数据表明这些RNA类型在调节肺肿瘤发生过程中必不可少。通过对该主题研究的综述，我们确定以下非编码RNA为肿瘤抑制因子：ts - 46、ts - 47、ts - 101、ts - 53、ts - 3676、ts - 4521（tRNA片段）、SNORD116 - 26、HBII - 420、SNORD15A、SNORA42（小核仁RNA）、piRNA样 - 163、piR - 35127、piR - 46545（piRNA）、CHIAP2、LOC100420907、RPL13AP17（假基因）和uc.454（T - UCR）。我们还发现了具有促肿瘤功能的非编码RNA：tRF - Leu - CAG、tRNA - Leu、tRNA - Val（tRNA片段）、circ - RAD23B、circRNA 100146、circPVT1、circFGFR3、circ_0004015、circPUM1、circFLI1、circABCB10、circHIPK3（环状RNA）、SNORA42、SNORA3、SNORD46、SNORA21、SNORD28、SNORA47、SNORD66、SNORA68、SNORA78（小核仁RNA）、piR - 65、piR - 34871、piR - 52200、piR651（piRNA）、hY4 5'片段（YRNA）、FAM83A - AS1、WRAP53、NKX2 - 1 - AS1（天然反义转录本）、DUXAP8、SFTA1P（假基因转录本）、uc.338、uc.339（T - UCR）和hTERC。
Zotero 插件