The Herbert Mast Cell Disorders Center, Laboratory of Allergy and Clinical Immunology, Meir Medical Center, Kfar Saba 4428164, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Int J Mol Sci. 2019 Apr 30;20(9):2145. doi: 10.3390/ijms20092145.
Allergic inflammation is accompanied by the coordinated expression of numerous genes and proteins that initiate, sustain, and propagate immune responses and tissue remodeling. MicroRNAs (miRNAs) are a large class of small regulatory molecules that are able to control the translation of target mRNAs and consequently regulate various biological processes at the posttranscriptional level. MiRNA profiles have been identified in multiple allergic inflammatory diseases and in the tumor microenvironment. Mast cells have been found to co-localize within the above conditions. More specifically, in addition to being essential in initiating the allergic response, mast cells play a key role in both innate and adaptive immunity as well as in modulating tumor growth. This review summarizes the possible role of various miRNAs in the above-mentioned processes wherein mast cells have been found to be involved. Understanding the role of miRNAs in mast cell activation and function may serve as an important tool in developing diagnostic as well as therapeutic approaches in mast cell-dependent pathological conditions.
变应性炎症伴随着大量基因和蛋白质的协调表达，这些基因和蛋白质启动、维持和传播免疫反应和组织重塑。MicroRNAs（miRNAs）是一大类小分子调节分子，能够控制靶 mRNA 的翻译，从而在转录后水平上调节各种生物学过程。已经在多种变应性炎症性疾病和肿瘤微环境中鉴定出 miRNA 谱。已经发现肥大细胞在上述条件下共同定位于。更具体地说，除了在启动过敏反应中是必不可少的之外，肥大细胞在先天和适应性免疫以及调节肿瘤生长中也发挥关键作用。这篇综述总结了各种 miRNA 在肥大细胞参与的上述过程中的可能作用。了解 miRNA 在肥大细胞激活和功能中的作用可能成为开发肥大细胞依赖性病理条件下诊断和治疗方法的重要工具。
