University of Pittsburgh, Department of Medicine, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA 15261, USA.
Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Trends Immunol. 2019 Jun;40(6):469-471. doi: 10.1016/j.it.2019.04.007. Epub 2019 Apr 30.
A recent study shows that the commensal fungus Candida albicans is an inducer of differentiation of human CD4 Th17 cells that harbor heterologous specificity for other fungi, which may explain evolutionary benefits of C. albicans as a commensal microbe (Bacher et al. Cell 2019;176;1340-1355). However, Th17 cells that are crossreactive to Aspergillus fumigatus antigens can also drive exaggerated airway inflammation in humans.
最近的一项研究表明，共生真菌白色念珠菌是人类 CD4 Th17 细胞分化的诱导剂，这些细胞对其他真菌具有异源特异性，这可能解释了白色念珠菌作为共生微生物的进化优势（Bacher 等人，Cell 2019；176；1340-1355）。然而，对烟曲霉抗原具有交叉反应性的 Th17 细胞也可以在人类中引发过度的气道炎症。
