真菌在我们中间：内部的敌友。
Fungus Among Us: The Frenemies Within.
机构信息
University of Pittsburgh, Department of Medicine, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA 15261, USA.
Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
出版信息
Trends Immunol. 2019 Jun;40(6):469-471. doi: 10.1016/j.it.2019.04.007. Epub 2019 Apr 30.
Abstract
A recent study shows that the commensal fungus Candida albicans is an inducer of differentiation of human CD4 Th17 cells that harbor heterologous specificity for other fungi, which may explain evolutionary benefits of C. albicans as a commensal microbe (Bacher et al. Cell 2019;176;1340-1355). However, Th17 cells that are crossreactive to Aspergillus fumigatus antigens can also drive exaggerated airway inflammation in humans.
摘要
最近的一项研究表明，共生真菌白色念珠菌是人类 CD4 Th17 细胞分化的诱导剂，这些细胞对其他真菌具有异源特异性，这可能解释了白色念珠菌作为共生微生物的进化优势（Bacher 等人，Cell 2019；176；1340-1355）。然而，对烟曲霉抗原具有交叉反应性的 Th17 细胞也可以在人类中引发过度的气道炎症。
相似文献
1
Fungus Among Us: The Frenemies Within.真菌在我们中间：内部的敌友。
Trends Immunol. 2019 Jun;40(6):469-471. doi: 10.1016/j.it.2019.04.007. Epub 2019 Apr 30.
2
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans.人类抗真菌 Th17 免疫和病理学依赖于对白念珠菌的交叉反应性。
Cell. 2019 Mar 7;176(6):1340-1355.e15. doi: 10.1016/j.cell.2019.01.041. Epub 2019 Feb 21.
3
Staged development of long-lived T-cell receptor αβ T17 resident memory T-cell population to Candida albicans after skin infection.皮肤感染白色念珠菌后，长寿 T 细胞受体 αβ T17 驻留记忆 T 细胞群体的分阶段发育。
J Allergy Clin Immunol. 2018 Aug;142(2):647-662. doi: 10.1016/j.jaci.2017.09.042. Epub 2017 Nov 9.
4
Candida and candidiasis in HIV-infected patients: where commensalism, opportunistic behavior and frank pathogenicity lose their borders.HIV 感染者中的念珠菌和念珠菌病：共生、机会主义行为和明显的致病性失去界限的地方。
AIDS. 2012 Jul 31;26(12):1457-72. doi: 10.1097/QAD.0b013e3283536ba8.
5
Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis.白念珠菌菌丝膜诱导分化的 Th17 细胞预防口腔念珠菌病。
FEMS Yeast Res. 2018 May 1;18(3). doi: 10.1093/femsyr/foy018.
6
Oral candidosis in relation to oral immunity.与口腔免疫相关的口腔念珠菌病
J Oral Pathol Med. 2014 Sep;43(8):563-9. doi: 10.1111/jop.12120. Epub 2013 Oct 9.
7
Adaptive immune responses to Candida albicans infection.针对白色念珠菌感染的适应性免疫反应。
Virulence. 2015;6(4):327-37. doi: 10.1080/21505594.2015.1004977. Epub 2015 Jan 21.
8
Identification of virulence determinants of the human pathogenic fungi Aspergillus fumigatus and Candida albicans by proteomics.通过蛋白质组学鉴定人类致病性真菌烟曲霉和白念珠菌的毒力决定因素。
Int J Med Microbiol. 2011 Jun;301(5):368-77. doi: 10.1016/j.ijmm.2011.04.001. Epub 2011 May 12.
9
SOCS3 ablation enhances DC-derived Th17 immune response against Candida albicans by activating IL-6/STAT3 in vitro.SOCS3 缺失通过体外激活 IL-6/STAT3 增强树突状细胞来源的 Th17 免疫应答对抗白色念珠菌。
Life Sci. 2019 Apr 1;222:183-194. doi: 10.1016/j.lfs.2019.03.009. Epub 2019 Mar 6.
10
In vitro generation of microbe-specific human Th17 cells.体外生成微生物特异性人Th17细胞。
Methods Mol Biol. 2014;1193:97-104. doi: 10.1007/978-1-4939-1212-4_10.
引用本文的文献
1
T cell responses to control fungal infection in an immunological memory lens.T 细胞在免疫记忆晶状体中对控制真菌感染的反应。
Front Immunol. 2022 Sep 13;13:905867. doi: 10.3389/fimmu.2022.905867. eCollection 2022.
2
Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.白色念珠菌在肠道定植过程中振荡 UME6 表达，从而引发系统性 Th17 保护性免疫。
Cell Rep. 2022 May 17;39(7):110837. doi: 10.1016/j.celrep.2022.110837.
3
Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis.口腔上皮细胞的 IL-22/STAT3 信号通路赋予了 IL-17 介导的口腔黏膜念珠菌病免疫能力。
Sci Immunol. 2020 Jun 5;5(48). doi: 10.1126/sciimmunol.aba0570.
本文引用的文献
1
Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses.共生白念珠菌正向调节系统性 Th17 免疫应答。
Cell Host Microbe. 2019 Mar 13;25(3):404-417.e6. doi: 10.1016/j.chom.2019.02.004.
2
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans.人类抗真菌 Th17 免疫和病理学依赖于对白念珠菌的交叉反应性。
Cell. 2019 Mar 7;176(6):1340-1355.e15. doi: 10.1016/j.cell.2019.01.041. Epub 2019 Feb 21.
3
Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs.分段丝状细菌通过诱导表达双 TCR 的肠肺轴 Th17 细胞引发肺部自身免疫。
Cell Host Microbe. 2017 Nov 8;22(5):697-704.e4. doi: 10.1016/j.chom.2017.10.007.
4
Gut-Busters: IL-17 Ain't Afraid of No IL-23.肠道破坏者：白细胞介素-17不惧白细胞介素-23。
Immunity. 2015 Oct 20;43(4):620-2. doi: 10.1016/j.immuni.2015.10.001.
5
IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans.白细胞介素-17介导的对机会性真菌病原体白色念珠菌的免疫
J Immunol. 2015 Aug 1;195(3):780-8. doi: 10.4049/jimmunol.1500909.
6
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens.肠道 TH17 细胞对共生细菌抗原的特异性聚焦。
Nature. 2014 Jun 5;510(7503):152-6. doi: 10.1038/nature13279. Epub 2014 Apr 13.
7
NDV-3 protects mice from vulvovaginal candidiasis through T- and B-cell immune response.新城疫病毒-3 通过 T 细胞和 B 细胞免疫应答保护小鼠免受阴道念珠菌病的侵害。
Vaccine. 2013 Nov 12;31(47):5549-56. doi: 10.1016/j.vaccine.2013.09.016. Epub 2013 Sep 21.
8
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.共生真菌与 C 型凝集素受体 Dectin-1 之间的相互作用影响结肠炎。
Science. 2012 Jun 8;336(6086):1314-7. doi: 10.1126/science.1221789. Epub 2012 Jun 6.
9
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial.司库奇尤单抗，一种人源抗白细胞介素-17A 单克隆抗体，用于中重度克罗恩病：一项随机、双盲、安慰剂对照试验的意外结果。
Gut. 2012 Dec;61(12):1693-700. doi: 10.1136/gutjnl-2011-301668. Epub 2012 May 17.
10
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis.肠道微生物群诱导的促炎 T 细胞应答促进实验性自身免疫性脑脊髓炎。
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1(Suppl 1):4615-22. doi: 10.1073/pnas.1000082107. Epub 2010 Jul 26.
Zotero 插件