Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Trends Endocrinol Metab. 2019 Jun;30(6):347-356. doi: 10.1016/j.tem.2019.04.003. Epub 2019 May 2.
Research over the past century indicates that the daily timing of physical activity impacts on both immediate performance and long-term training efficacy. Recently, several molecular connections between circadian clocks and exercise physiology have been identified. Circadian clocks are protein-based oscillators that enable anticipation of daily environmental cycles. Cell-autonomous clocks are present in almost all cells of the body, and their timing is set by a variety of internal and external signals, including hormones and dietary intake. Improved understanding of the relationship between molecular clocks and exercise will benefit professional athletes and public health guidelines for the general population. We discuss here the role of circadian clocks in exercise, and explore time-of-day effects and the proposed molecular and physiological mechanisms.
一个世纪以来的研究表明，日常活动的时间安排会影响即时表现和长期训练效果。最近，人们已经发现了生物钟与运动生理学之间的一些分子联系。生物钟是基于蛋白质的振荡器，能够预测日常环境周期。自主时钟存在于体内几乎所有的细胞中，它们的时间由各种内部和外部信号设定，包括激素和饮食摄入。改善对分子钟与运动之间关系的理解将使职业运动员和普通人群的公共卫生指南受益。我们在这里讨论了生物钟在运动中的作用，并探讨了时间对运动的影响以及提出的分子和生理机制。
