Registrar Oral Surgery, Nantes University, Nantes University Hospital, Nantes, France.
Nantes University, Nantes University Hospital, Inserm UMR-S 1229, RMeS, Nantes, France.
J Stomatol Oral Maxillofac Surg. 2020 Jun;121(3):308-311. doi: 10.1016/j.jormas.2019.04.014. Epub 2019 May 2.
Gingival enlargements (GEs) can be caused by local, systemic diseases or drugs. Three molecules can be responsible of GEs: ciclosporin, phenytoin and calcium channel blockers (CCBs). We report the case of a 56-year-old male treated by Amlodipine, a CCB, for hypertension for many years and who recently developed a severe GE affecting both mandibular and maxillary arches inducing dental malposition. The histological examination showed non-specific inflammation with a predominance of lymphocytes. Amlodipine was suspected and suspended in agreement with his physician. One month later, the enlargement significantly reduced but GE was so severe and dental malposition so marked that all the teeth but the canines were extracted. No recurrence was noted one year later. This exceptional case should encourage every practitioner to be vigilant with patient treated with CCBs and their potential side effects and consequences.
牙龈肿大（GE）可由局部、全身疾病或药物引起。有三种分子可能导致 GE：环孢素、苯妥英钠和钙通道阻滞剂（CCB）。我们报告了一例 56 岁男性的病例，他多年来因高血压接受氨氯地平（一种 CCB）治疗，最近出现严重的 GE，影响上下颌弓，导致牙齿错位。组织学检查显示非特异性炎症，以淋巴细胞为主。怀疑是氨氯地平引起的，并经其医生同意停用。一个月后，肿大明显缩小，但 GE 非常严重，牙齿错位非常明显，除了犬齿外所有牙齿都被拔除。一年后未再复发。这个特殊的病例应该提醒每一位医生对使用 CCB 及其潜在副作用和后果的患者保持警惕。
