骨髓增生异常综合征中 microRNA-661 的上调通过 p53 激活诱导细胞凋亡，并与总生存期缩短相关。

MicroRNA-661 upregulation in myelodysplastic syndromes induces apoptosis through p53 activation and associates with decreased overall survival.

机构信息

Department of Laboratory Medicine, Chosun University College of Medicine, Gwangju, Republic of Korea.

Department of Laboratory Medicine, International St. Mary's Hospital, Catholic Kwandong University, Incheon, Republic of Korea.

出版信息

Leuk Lymphoma. 2019 Nov;60(11):2779-2786. doi: 10.1080/10428194.2019.1608528. Epub 2019 May 6.

DOI:10.1080/10428194.2019.1608528

PMID:31056984

Abstract

MicroRNA (miRNA) dysregulation contributes to myelodysplastic syndromes (MDS), and apoptosis is one of the pathogenic features of MDS. We investigated the dysregulation of miRNA expression and its biological significance in MDS. We compared the expression profiles of miRNAs encoded by chromosome 8 in 65 patients with MDS and 11 controls, and analyzed the effect of the upregulated miRNA expression. We found that compared to the controls, miR-661 was upregulated by 5.28-fold in patients with MDS. Patients with high miR-661 expression showed significantly decreased overall survival. study results demonstrated that transfection with a miR-661 mimic induced apoptosis through the activation of p53. These findings suggest that high miR-661 expression can be associated with decreased overall survival and recapitulates apoptosis, the characteristic feature of MDS.

摘要

微小 RNA（miRNA）失调与骨髓增生异常综合征（MDS）有关，而细胞凋亡是 MDS 的发病特征之一。我们研究了 miRNA 表达失调及其在 MDS 中的生物学意义。我们比较了 65 例 MDS 患者和 11 例对照者染色体 8 编码 miRNA 的表达谱，并分析了上调 miRNA 表达的效应。我们发现，与对照组相比，MDS 患者 miR-661 的表达上调了 5.28 倍。miR-661 高表达的患者总生存率显著降低。研究结果表明，转染 miR-661 模拟物通过激活 p53 诱导细胞凋亡。这些发现表明，miR-661 高表达可能与总生存率降低有关，并重现了 MDS 的特征性特征——细胞凋亡。