Department of Oriental Medicinal Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea.
Snow White Factory Co. Ltd, Seoul, Korea.
Photochem Photobiol. 2019 Nov;95(6):1412-1423. doi: 10.1111/php.13116. Epub 2019 Jun 12.
Ginsenosides are compounds responsible for the primary pharmacological effects of American ginseng. Compound-Y (C-Y) is a minor ginsenoside and a metabolite of Panax ginseng. In this study, we investigated the protective effect of ginsenoside UVB-irradiated NHDFs and its potential for use as an antihyperpigmentation agent through ginsenoside C-Y as a functional food and cosmetic ingredient. Ginsenoside C-Y is a natural antioxidant isolated from the American ginseng PDD-ginsenoside. Our data showed that ginsenoside C-Y block UVB-exposed ROS, restrict MMP-1 production and promote procollagen type I synthesis. Interestingly, ginsenoside C-Y suppresses UVB-exposed VEGF, and TNF-α secretion, could be related with NFAT signal path. Ginsenoside C-Y has exhibited photoaging effects by increasing TGF-β1 level, fortifying Nrf2 nuclear translocation and restricting AP-1 and MAPK phosphorylation. Assessment of the melanogenic response indicated that ginsenoside C-Y inhibited melanin secretion and tyrosinase activity and decreased melanin content in Melan-a and zebrafish embryos. These results suggest that ginsenoside C-Y can be used as a potential botanical agent to protect premature skin from UVB-induced photodamage and prevent skin hyperpigmentation.
人参皂苷是导致西洋参主要药理作用的化合物。化合物 Y（C-Y）是一种次要的人参皂苷，也是人参的一种代谢产物。在这项研究中，我们研究了人参皂苷 UVB 辐照 NHDF 的保护作用及其作为功能性食品和化妆品成分的潜在用途，其功能成分是 C-Y 人参皂苷。C-Y 人参皂苷是从西洋参 PDD-人参皂苷中分离出来的天然抗氧化剂。我们的数据表明，C-Y 人参皂苷可阻止 UVB 暴露产生的 ROS，限制 MMP-1 的产生，并促进原胶原蛋白 I 的合成。有趣的是，C-Y 人参皂苷抑制 UVB 暴露产生的 VEGF 和 TNF-α的分泌，这可能与 NFAT 信号通路有关。C-Y 人参皂苷通过增加 TGF-β1 水平、加强 Nrf2 核易位以及限制 AP-1 和 MAPK 磷酸化来显示光老化作用。对黑色素生成反应的评估表明，C-Y 人参皂苷可抑制黑色素分泌和酪氨酸酶活性，并减少黑素细胞和斑马鱼胚胎中的黑色素含量。这些结果表明，C-Y 人参皂苷可用作潜在的植物药，以保护皮肤免受 UVB 诱导的光损伤，并预防皮肤色素沉着过度。
