磁共振波谱评估心力衰竭患者的心脏代谢。

Evaluation of Cardiac Metabolism by Magnetic Resonance Spectroscopy in Heart Failure.

机构信息

Division of Cardiology, Ospedale Accreditato Villa dei Fiori, Acerra, Naples, Italy; Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Division of Cardiology, Ospedale Accreditato Villa dei Fiori, Acerra, Naples, Italy.

出版信息

Heart Fail Clin. 2019 Jul;15(3):421-433. doi: 10.1016/j.hfc.2019.02.010. Epub 2019 Apr 5.

DOI:10.1016/j.hfc.2019.02.010

PMID:31079700

Abstract

Alterations in myocardial energy metabolism as demonstrated by magnetic resonance spectroscopy (MRS) are critically involved in heart failure development. H-MRS allows investigation of the role of myocardial lipid accumulation in the pathophysiology of heart failure. With P-MRS, the most useful parameter is the cardiac adenosine triphosphate to phosphocreatine ratio, which is typically reduced in the failing heart and correlates with cardiac functional status. Currently, MRS is mostly limited to the research setting, but recent technical and methodological developments might substantially improve its clinical applicability for initial characterization and successive monitoring of patients with heart failure.

摘要

磁共振波谱（MRS）显示心肌能量代谢的改变与心力衰竭的发生发展密切相关。MRS 可研究心肌脂质堆积在心力衰竭病理生理学中的作用。应用磷 MRS，最有用的参数是心脏三磷酸腺苷与磷酸肌酸的比值，该比值在心衰时降低，与心功能状态相关。目前，MRS 主要限于研究领域，但最近的技术和方法学的发展可能会大大提高其在心力衰竭患者的初步特征和连续监测中的临床应用价值。