Recent advances in the detection of 17β-estradiol in food matrices: A review.

Pollution of endocrine disrupting chemicals has become a global issue. As one of the hormonally active compounds, 17β-estradiol produces the strongest estrogenic effect when it enters the organism exogenously including food intakes, bringing potential harmfulness such as malfunction of the endocrine system. Therefore, in order to assure food safety and avoid potential risks of 17β-estradiol to humans, it is of great significance to develop rapid, sensitive and selective approaches for the detection of 17β-estradiol in food matrices. In this review, the harmfulness and main sources of 17β-estradiol are firstly introduced, followed by the description of the principles and applications of different approaches for 17β-estradiol detection including high performance liquid chromatography, electrochemistry, Raman spectroscopy, fluorescence and colorimetry. Particularly, applications in detecting 17β-estradiol in food matrices over the years of 2010-2018 are discussed. Finally, advantages and limitations of these detection methods are highlighted and perspectives on future developments in the detection methods for 17β-estradiol are also proposed. Although many detection approaches can achieve trace or ultratrace detection of 17β-estradiol, further studies should be focused on the development of in-situ and real-time methods to monitor and evaluate 17β-estradiol for food safety.