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一名无皮疹的年轻免疫功能正常宿主脑脊液(CSF)分析显示为水痘带状疱疹性脑膜炎伴脑脊液低糖血症

Varicella Zoster Meningitis with Hypoglycorrhachia on Cerebrospinal Fluid (CSF) Analysis in a Young Immunocompetent Host without a Rash.

作者信息

Fadhel Mustafa, Campbell Natasha, Patel Swapnil, Mushtaq Arman, Fune Lito, Asif Arif, Hossain Mohammad A

机构信息

Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ, USA.

出版信息

Am J Case Rep. 2019 May 16;20:701-704. doi: 10.12659/AJCR.915300.

Abstract

BACKGROUND Varicella zoster virus (VZV) is a common viral infection, with primary infection presenting as fevers and pruritic vesicular rash. After staying dormant in the dorsal root ganglia, reactivation can lead to secondary infection. Meningitis is a rare a complication of VZV infection. CASE REPORT We report a case of a 44-year-old woman with no past medical history, presenting with severe frontal headache without meningeal signs or fevers, found to have VZV meningitis. CSF analysis revealed hypoglycorrhachia and she was treated successfully with combination of intravenous acyclovir and oral valacyclovir. CONCLUSIONS VZV meningitis can present with subtle clinical signs and symptoms and should be considered as a possible etiology for headaches without identifiable cause.

摘要

背景

水痘带状疱疹病毒(VZV)是一种常见的病毒感染,原发性感染表现为发热和瘙痒性水疱疹。在潜伏于背根神经节后,病毒再激活可导致继发性感染。脑膜炎是VZV感染的一种罕见并发症。病例报告:我们报告一例44岁无既往病史的女性,表现为严重的前额头痛,无脑膜刺激征或发热,经诊断为VZV脑膜炎。脑脊液分析显示脑脊液低糖,患者通过静脉注射阿昔洛韦和口服伐昔洛韦联合治疗成功治愈。结论:VZV脑膜炎可能表现出不明显的临床体征和症状,对于无明确病因的头痛应考虑其为可能的病因。

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