Kumar Aman, Kumari Niti, Nallabelli Nayudu, Prasad Rajendra
1Department of Biochemistry, Postgraduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, India.
2Department of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, India.
Indian J Clin Biochem. 2019 Apr;34(2):123-132. doi: 10.1007/s12291-019-00828-x. Epub 2019 Apr 3.
Histone modifications occupy an essential position in the epigenetic landscape of the cell, and their alterations have been linked to cancers. Histone 3 lysine 4 (H3K4) methylation has emerged as a critical epigenetic cue for the regulation of gene transcription through dynamic modulation by several H3K4 methyltransferases (writers) and demethylases (erasers). Any disturbance in the delicate balance of writers and erasers can result in the mis-regulation of H3K4 methylation, which has been demonstrated in several human cancers. Therefore, H3K4 methylation has been recognized as a putative therapeutic or prognostic tool and drug trials of different inhibitors of this process have demonstrated promising results. Henceforth, more detailed knowledge of H3K4 methylation is utmost important for elucidating the complex cellular processes, which might help in improving the disease outcome. The primary focus of this review will be directed on deciphering the role of H3K4 methylation along with its writers/erasers in different cancers.
组蛋白修饰在细胞的表观遗传格局中占据重要地位，其改变与癌症相关。组蛋白H3赖氨酸4（H3K4）甲基化已成为一种关键的表观遗传线索，通过几种H3K4甲基转移酶（写入器）和去甲基化酶（擦除器）的动态调节来调控基因转录。写入器和擦除器之间微妙平衡的任何干扰都可能导致H3K4甲基化的失调，这在几种人类癌症中已得到证实。因此，H3K4甲基化已被视为一种潜在的治疗或预后工具，针对该过程不同抑制剂的药物试验已显示出有希望的结果。此后，更详细地了解H3K4甲基化对于阐明复杂的细胞过程至关重要，这可能有助于改善疾病预后。本综述的主要重点将是解读H3K4甲基化及其写入器/擦除器在不同癌症中的作用。
