量化新生物标志物的附加价值：方法与误区
Quantifying the added value of new biomarkers: how and how not.
作者信息
Cook Nancy R
机构信息
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Ave. East, Boston, MA 02215 USA.
出版信息
Diagn Progn Res. 2018 Jul 11;2:14. doi: 10.1186/s41512-018-0037-2. eCollection 2018.
Abstract
Over the past few decades, interest in biomarkers to enhance predictive modeling has soared. Methodology for evaluating these has also been an active area of research. There are now several performance measures available for quantifying the added value of biomarkers. This commentary provides an overview of methods currently used to evaluate new biomarkers, describes their strengths and limitations, and offers some suggestions on their use.
摘要
在过去几十年里，人们对用于改进预测模型的生物标志物的兴趣急剧上升。评估这些生物标志物的方法也是一个活跃的研究领域。现在有几种性能指标可用于量化生物标志物的附加值。本评论概述了目前用于评估新型生物标志物的方法，描述了它们的优点和局限性，并就其使用提出了一些建议。
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