通过长度编码的 aerolysin 纳米孔集成三螺旋分子开关对阿尔茨海默病的多重生物标志物进行同步筛选。
Synchronous screening of multiplexed biomarkers of Alzheimer's disease by a length-encoded aerolysin nanopore-integrated triple-helix molecular switch.
机构信息
Changsha University of Science and Technology, School of Chemistry and Food Engineering, Changsha, 410114, P. R. China.
出版信息
Chem Commun (Camb). 2019 May 30;55(45):6433-6436. doi: 10.1039/c9cc02065a.
Herein, we developed a versatile strategy for the synchronous screening of biomarkers of Alzheimer's disease (AD) by incorporating the high-resolution discrimination of an aerolysin nanopore to length-encoded oligonucleotides and the signal transduction of a triple-helix molecular switch (TMS). This assay is adapted to quantitatively compare multiplexed targets of very different native contents without tedious chemical labelling.
在此，我们开发了一种通用策略，通过将 aerolysin 纳米孔的高分辨率区分与三螺旋分子开关（TMS）的信号转导相结合，对阿尔茨海默病（AD）的生物标志物进行同步筛选。该测定法适用于在无需繁琐化学标记的情况下，定量比较非常不同天然含量的多重靶标。
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