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基质金属蛋白酶在卵巢癌中的预后价值。

The prognostic values of matrix metalloproteinases in ovarian cancer.

作者信息

Zeng Linchai, Qian Jie, Zhu Fangfang, Wu Fang, Zhao Hongqin, Zhu Haiyan

机构信息

Department of Gynaecology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

Department of Clinical Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

出版信息

J Int Med Res. 2020 Jan;48(1):300060519825983. doi: 10.1177/0300060519825983. Epub 2019 May 17.

DOI:10.1177/0300060519825983
PMID:31099295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7140190/
Abstract

OBJECTIVE

To investigate the prognostic significance of 23 matrix metalloproteinase () genes in patients diagnosed with ovarian carcinoma.

METHODS

The prognostic significance of 23 genes in patients diagnosed with ovarian carcinoma was investigated using the Kaplan–Meier plotter (KM plotter), which uses the gene expression data and overall survival information of patients with ovarian cancer that were downloaded from the Gene Expression Omnibus, Cancer Biomedical Informatics Grid and The Cancer Genome Atlas cancer datasets. The correlation between mRNA levels of individual MMPs (MMP2, MMP9, MMP10, MMP12, MMP13 and MMP25) and clinicopathological features (histological subtype, pathological grade and clinical stage) were investigated. The MMP protein level profiles in normal ovarian tissues and ovarian cancer tissues were examined using the Human Protein Atlas database.

RESULTS

The results showed that high mRNA levels of MMP2 and MMP13 were associated with a worse overall survival in patients with ovarian cancer, whereas high mRNA levels of MMP9, MMP10, MMP12 and MMP25 were associated with a better overall survival. The protein levels of MMP2, MMP9, MMP10 and MMP25 in ovarian cancer tissues were elevated compared with normal ovarian tissues.

CONCLUSIONS

This study demonstrated that MMPs can be a reliable prognostic biomarker for ovarian cancer.

摘要

目的

探讨23种基质金属蛋白酶（MMP）基因在卵巢癌患者中的预后意义。

方法

使用Kaplan-Meier绘图仪（KM绘图仪）研究23种MMP基因在卵巢癌患者中的预后意义，该绘图仪使用从基因表达综合数据库、癌症生物医学信息网格和癌症基因组图谱癌症数据集中下载的卵巢癌患者的基因表达数据和总生存信息。研究了个体MMP（MMP2、MMP9、MMP10、MMP12、MMP13和MMP25）的mRNA水平与临床病理特征（组织学亚型、病理分级和临床分期）之间的相关性。使用人类蛋白质图谱数据库检查正常卵巢组织和卵巢癌组织中的MMP蛋白水平概况。

结果

结果显示，MMP2和MMP13的高mRNA水平与卵巢癌患者较差的总生存相关，而MMP9、MMP10、MMP12和MMP25的高mRNA水平与较好的总生存相关。与正常卵巢组织相比，卵巢癌组织中MMP2、MMP9、MMP10和MMP25的蛋白水平升高。

结论

本研究表明，MMPs可作为卵巢癌可靠的预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15b/7140190/1aa5b04224f9/10.1177_0300060519825983-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15b/7140190/1aa5b04224f9/10.1177_0300060519825983-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15b/7140190/1aa5b04224f9/10.1177_0300060519825983-fig1.jpg

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